| 产品描述： | XEN723 is a novel and potent thiazolylimidazolidinone inhibitor of Stearoyl-CoA Desaturase (SCD1) with IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively |
| 靶点： |
IC50: 45 nM (SCD1 in Mouse), 524 nM (SCD1 in HepG2 cell);Dehydrogenase;Stearoyl-CoADesaturase(SCD) |
| 体外研究： |
XEN723 is a novel and potent thiazolylimidazolidinone inhibitor of Stearoyl-CoA Desaturase (SCD1) with IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively. XEN723 demonstrates an improvement in SCD1 in vitro potency of more than 560-fold compare to the original high throughput screen (HTS) hit. |
| 参考文献： |
1. Sun S, et al. Systematic evaluation of amide bioisosteres leading to the discovery of novel and potent thiazolylimidazolidinone inhibitors of SCD1 for the treatment of metabolic diseases. Bioorg Med Chem Lett. 2014 Jan 15;24(2):520-5. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 备注： |
XEN723 是一种新型且有效的硬脂酰辅酶 A 去饱和酶 (SCD1) 的噻唑基咪唑烷酮抑制剂，在小鼠和 HepG2 细胞中的 IC50 值分别为 45 和 524 nM。 |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.35 ml |
11.751 ml |
23.503 ml |
| 5 mM |
0.47 ml |
2.35 ml |
4.701 ml |
| 10 mM |
0.235 ml |
1.175 ml |
2.35 ml |
| 50 mM |
0.047 ml |
0.235 ml |
0.47 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京