| 产品描述： | TSHR拮抗剂S37是促甲状腺素受体(thyrotropin receptor, TSHR)的一种选择性和竞争性的拮抗剂 |
| 靶点： |
TSHReceptor |
| 体内研究： |
TSHR antagonist S37 has no toxicity and a remarkable 53% oral bioavailability in mice, indicating by initial in vivo pharmacokinetic studies |
| 细胞实验： |
Cell lines: HEK293 cells, HEK-TSHR cells Concentrations: 1-100 μM Incubation Time: 1.5 h, 18 h Method: HEK293T-TSHR cells (8 × 104 per well) are seeded onto a 96-well plate and grown for 48 h. The cells are treated for 18 h with S37 ranging from 10 to 100 μM or with the equivalent concentration of DMSO as solvent control. Cell viability is measured using the alamarBlue assay. |
| 动物实验： |
Animal Models: SWISS (CD1) mice Dosages: 1 mg/kg (i.v.), 10 mg/kg (p.o.) Administration: i.v., p.o. |
| 参考文献： |
1. Neumann S, et al. Eur Thyroid J. 2020 Dec;9(Suppl 1):59-65. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.171 ml |
10.856 ml |
21.712 ml |
| 5 mM |
0.434 ml |
2.171 ml |
4.342 ml |
| 10 mM |
0.217 ml |
1.086 ml |
2.171 ml |
| 50 mM |
0.043 ml |
0.217 ml |
0.434 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京