货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
V54127-1ml	10mM in DMSO	￥300.00 V54127-1ml ￥300.00 3-5天	0 货期：3-5天	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

V54127-1ml

10mM in DMSO

￥300.00

货期：3-5天

产品描述：

FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A). FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities

靶点：

IC50: 4.9 μM (Methionine S-adenosyltransferase 2A (MAT2A));Wnt/beta-catenin;MethionineAdenosyltransferase(MAT)

体外研究：

FIDAS-3 (3 μM; 7 days; LS174T cells) treatment significantly inhibits the proliferation of LS174T cells.

FIDAS-3 (3-10 μM) treatment inhibits the expression of c-Myc and cyclinD1 in LS174T CRC cells. And FIDAS-3 induces the expression of cell cycle inhibitor, p21WAF1/CIP1.

FIDAS-3 (10 μM; 36 h) treatment reduces the levels of both S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in LS174T cells.

体内研究：

FIDAS-3 (20 mg/kg; intraperitoneal injection; daily; for one months; C57BL/6J athymic nude mice) treatment significantly inhibits the growth of xenograft tumors. Animal Model: C57BL/6J athymic nude mice (6-8 week) injected with LS174 cells Dosage: 20 mg/kg Administration: Intraperitoneal injection; daily; for one months Result: Significantly inhibited the growth of xenograft tumors.

参考文献：

1. Zhang W, et al. Fluorinated N,N-dialkylaminostilbenes repress colon cancer by targeting methionine S-adenosyltransferase 2A. ACS Chem Biol. 2013 Apr 19;8(4):796-803.

2. Zhang W, et al. Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. J Med Chem. 2011 Mar 10;54(5):1288-97.

溶解性：

Soluble in DMSO

保存条件：

-80℃（运输条件：冰袋低温运输）

备注：

FIDAS-3 是一种二苯乙烯衍生物，也是一种强效的 Wnt 抑制剂，对甲硫氨酸腺苷转移酶 2A (MAT2A) 的 IC50 为 4.9 μM。FIDAS-3 与 S-腺苷甲硫氨酸 (SAM) 有效竞争 MAT2A 结合，并具有抗癌活性。

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.857 ml	19.283 ml	38.567 ml
5 mM	0.771 ml	3.857 ml	7.713 ml
10 mM	0.386 ml	1.928 ml	3.857 ml
50 mM	0.077 ml	0.386 ml	0.771 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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