| 产品描述： | SK33, a trifluoromethylated enobosarm analog, is a potent, and tissue selective anti-androgen. SK33reduces androgen receptor (AR) transcriptional activity |
| 靶点： |
Androgen Receptor;AndrogenReceptor |
| 体外研究： |
In LNCaPAR+ cells, SK33, demonstrates a significantly potent activity with IC50=0.2 μM. SK33 decreases cells entering S-phase in LNCaP cells. Treatment of LNCaP/BicR cells with increasing concentrations of SK33 for 96 hours results in a dose-dependent response and an inhibition of cell growth, with IC50 of approximately 5 μM for SK33. |
| 体内研究： |
SK33 (50 mg/kg; s.c.; 24 hours) inhibits AR transcriptional activity. Animal Model:ARE-Luc mice Dosage:50 mg/kg Administration:Subcutaneously; 24 hours Result:Inhibited AR transcriptional activity. |
| 参考文献： |
1. Dart DA, et al. Novel Trifluoromethylated Enobosarm Analogues with Potent Aniandrogenic Activity In Vitro and Tissue Selectivity In Vivo.Mol Cancer Ther. 2018 Sep;17(9):1846-1858. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
1.999 ml |
9.994 ml |
19.988 ml |
| 5 mM |
0.4 ml |
1.999 ml |
3.998 ml |
| 10 mM |
0.2 ml |
0.999 ml |
1.999 ml |
| 50 mM |
0.04 ml |
0.2 ml |
0.4 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京