| 产品描述： | Lavendustin A (RG-14355) is a potent, selective and ATP-competitive inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, with an IC50 of 11 nM. Lavendustin A does not inhibit protein kinase A or C. Lavendustin A can suppress VEGF-induced angiogenesis |
| 靶点： |
IC50: 11 nM (EGFR-associated tyrosine kinase);EGFR; Tyrosinase |
| 体外研究： |
Lavendustin A (5-50μM) 剂量依赖性地抑制卵巢分散培养物中的孕酮产生 |
| 体内研究： |
Lavendustin A (10 μg) 降低了 VEGF165 (250 ng) 处理的海绵的 133Xe 清除率和总纤维血管生长面积 |
| 参考文献： |
1. Onoda T, et, al. Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus. J Nat Prod. 1989 Nov-Dec;52(6):1252-7. 2. Hu DE, et, al. Suppression of VEGF-induced angiogenesis by the protein tyrosine kinase inhibitor, lavendustin A. Br J Pharmacol. 1995 Jan;114(2):262-8. 3. Whitehead SA, et, al. Protein tyrosine kinase activity of lavendustin A and the phytoestrogen genistein on progesterone synthesis in cultured rat ovarian cells. Fertil Steril. 2000 Mar;73(3):613-9. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.622 ml |
13.11 ml |
26.221 ml |
| 5 mM |
0.524 ml |
2.622 ml |
5.244 ml |
| 10 mM |
0.262 ml |
1.311 ml |
2.622 ml |
| 50 mM |
0.052 ml |
0.262 ml |
0.524 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
