| 产品描述： | Imisopasem manganese (M40403) is a manganese superoxide MnSOD non-peptidyl mimetic. |
| 靶点： |
Others |
| 体内研究： |
M40403 has shown efficacy in animal model disease states in which superoxide anions are thought to play a key role. M40403 inhibits the inflammatory response following the intrapleural injection of carrageenan in rats. All parameters of inflammation are attenuated by M40403 except for NOx, PGE2 and IL-10 which remains unaltered. Decreased apoptosis of the large and particularly the small bowel and marked recovery of both lymphoid and hematopoietic tissues occurs in the M40403 pre-treated mice |
| 动物实验： |
Rats: Male Sprague-Dawley rats are used in the study. M40403 (5-20mgkg-1), or an equivalent volume (0.3mL) of the vehicle (26mm sodium bicarbonate buffer, pH?8.1-8.3), is injected intraperitoneally (i.p.) 15min before carrageenan. At 4h after the injection of carrageenan, the animals are killed by inhalation of CO2. Mice: 30 mg dry powder M40403 is dissolved in 6.0 ml SBC adjusted to pH 8.3 with 1 M NaOH. This stock solution is diluted to 1.25 mg/mL in SBC. Two experimental models are tested. In one, the dose of IR is held constant at 8.5 Gy total body irradiation (TBI). The mice are injected i.p. with a single dose of 40 mg/kg, 30 mg/kg, 20 mg/kg or 10 mg/kg M40403. Thirty minutes later the mice receive 8.5 Gy total body irradiation (TBI). Control animals received 0.1 ml of SBC buffer prior to TBI. In the other model, groups of 20 mice receive either 6.5 or 7.5 Gy TBI. One half of each group is treated with 2.0 mg/kg M40403 i.p. and the other with SBC 30 min before TBI |
| 参考文献： |
1. Salvemini D, et al. Pharmacological manipulation of the inflammatory cascade by the superoxide dismutase mimetic,M40403. Br J Pharmacol. 2001 Feb;132(4):815-27. 2. Masini E, et al. Protective effects of M40403, a selective superoxide dismutase mimetic, in myocardial ischaemia and reperfusion injury in vivo. Br J Pharmacol. 2002 Jul;136(6):905-17. |
| 溶解性： |
Soluble in H2O |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.069 ml |
10.344 ml |
20.687 ml |
| 5 mM |
0.414 ml |
2.069 ml |
4.137 ml |
| 10 mM |
0.207 ml |
1.034 ml |
2.069 ml |
| 50 mM |
0.041 ml |
0.207 ml |
0.414 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京