| 产品描述: | Recilisib (ON 01210) is a radioprotectant, which can activate AKT, PI3K activities in cells |
| 靶点: |
PI3K;Akt; PI3K |
| 体内研究: |
Recilisib Sodium (500 mg/kg) significantly increases the rate of recovery and differentiation of primitive bone marrow myeloid progenitor cells in mice. Recilisib Sodium in combination with radiation reduces CFU numbers in mice, but the Recilisib Sodium-treated mice consistently retain a capability to form differentiated colonies. Recilisib Sodium treated mice have a progenitor cell population that is never completely depleted by radiation exposure |
| 参考文献: |
1. Kang AD, et al. ON01210.Na (Ex-RAD) mitigates radiation damage through activation of the AKT pathway. PLoS One. 2013;8(3):e58355. |
| 溶解性: |
Soluble in DMSO |
| 保存条件: |
-80℃(运输条件:冰袋低温运输) |
| 配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
| 1 mM |
2.969 ml |
14.846 ml |
29.692 ml |
| 5 mM |
0.594 ml |
2.969 ml |
5.938 ml |
| 10 mM |
0.297 ml |
1.485 ml |
2.969 ml |
| 50 mM |
0.059 ml |
0.297 ml |
0.594 ml |
|
| 注意: |
部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。 |