| 产品描述： | HBX 41108 is an uncompetitive inhibitor of ubiquitin-specific protease 7 (USP7) with an IC50 of 424 nM. HBX 41108 inhibits USP7-mediated p53 deubiquitination to stabilize p53 and inhibits cancer cell growth. HBX 41108 induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines |
| 靶点： |
Deubiquitinase;Apoptosis;DUB; p53 |
| 体内研究： |
HBX 41108 (100 mg/kg/day for 14 days, i.p.) 可促进糖尿病大鼠伤口愈合并降低其血糖水平。 |
| 参考文献： |
1. Colland F, et al. Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. Mol Cancer Ther. 2009 Aug;8(8):2286-95. 2. Colombo M, et al. Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem. 2010 Apr 6;5(4):552-8. |
| 溶解性： |
Soluble in DMSO |
| 保存条件： |
-80℃（运输条件：冰袋低温运输） |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
3.75 ml |
18.752 ml |
37.503 ml |
| 5 mM |
0.75 ml |
3.75 ml |
7.501 ml |
| 10 mM |
0.375 ml |
1.875 ml |
3.75 ml |
| 50 mM |
0.075 ml |
0.375 ml |
0.75 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京