货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
V56900-1ml	10mM in DMSO	￥3700.00 V56900-1ml ￥3700.00 3-5天	0 货期：3-5天	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

V56900-1ml

10mM in DMSO

￥3700.00

货期：3-5天

产品描述：

Voruciclib hydrochloride is an orally active and selective CDK inhibitor with Ki values of 0.626 nM-9.1 nM. Voruciclib hydrochloride potently blocks CDK9, the transcriptional regulator of MCL-1. Voruciclib hydrochloride represses expression of MCL-1 in multiple models of diffuse large B-cell lymphoma (DLBCL).

靶点：

CDK9/CycT1:1.68 nM (Ki); CDK9/cyc T2:0.626 nM (Ki); CDK6/cycD1:2.92 nM (Ki); CDK4/Cyc D1:3.96 nM (Ki); CDK1/cycB:5.4 nM (Ki); CDK1/cyc A:9.1 nM (Ki)

体外研究：

Combination of Voruciclib hydrochloride (200 mpk; Oral gavage) and Venetoclax (10 mpk, 1 mpk, 50 mpk, 25 mpk in U2932, RIVA, SU-DHL-4 and NU-DHL-1, respectively) leads to enhance tumor growth inhibition compared to either drug alone in U2932, RIVA, SU-DHL-4 (six days per week for 4 weeks), and NU-DHL-1 models (five days per week for 3 weeks) of DLBCL[1].

体内研究：

Voruciclib hydrochloride (0.5-5 µM; 6 hours) shows targeted downregulation of MCL-1 in both ABC and GCB subtypes.
Ki values for each target such as CDK9/cyc T2, CDK9/cyc T1, CDK6/cyc D1, CDK4/cyc D1, CDK1/cyc B, and CDK1/cyc A for Voruciclib hydrochloride are 0.626 nM, 1.68 nM, 2.92 nM, 3.96 nM, 5.4 nM, 9.1 nM, respectively.

参考文献：

1. Dey J, et al. Voruciclib, a clinical stage oral CDK9 inhibitor, represses MCL-1 and sensitizes high-risk Diffuse Large B-cell Lymphoma to BCL2 inhibition. Sci Rep. 2017 Dec 21;7(1):18007.

保存条件：

-80°C 12个月; -20°C 6个月, 干燥

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.975 ml	9.876 ml	19.751 ml
5 mM	0.395 ml	1.975 ml	3.95 ml
10 mM	0.198 ml	0.988 ml	1.975 ml
50 mM	0.04 ml	0.198 ml	0.395 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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