货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
V56907-1ml	10mM in DMSO	￥490.00 V56907-1ml ￥490.00 3-5天	0 货期：3-5天	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

V56907-1ml

10mM in DMSO

￥490.00

货期：3-5天

产品描述：

(Z)-Lanoconazole is the Z configuration of Lanoconazole. Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi in vitro and in vivo. Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis.

靶点：

IC50: antifungal

体外研究：

Lanoconazole (treatment for ear; 0.3%-3%; 6 days) dose-dependently suppressesTPA-induced irritant dermatitis, suppresses the production of neutrophil chemotactic factors such as keratinocyte-derived chemokine and macrophage inflammatory protein-2, and inhibited neutrophil infiltration to the inflammation site.
Lanoconazole (oral administration; 3, 10 or 30 mg/kg; once a day; 3 weeks) significantly inhibits C. neoformans compared with the saline control in normal mice. In addtion, it significantly reduces the growth of C. neoformans in the lungs and brains of MAIDS mice.

体内研究：

保存条件：

-80°C 6个月;-20°C 1个月

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.127 ml	15.633 ml	31.267 ml
5 mM	0.625 ml	3.127 ml	6.253 ml
10 mM	0.313 ml	1.563 ml	3.127 ml
50 mM	0.063 ml	0.313 ml	0.625 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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