| 产品描述： | YF-2 hydrochloride is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease[1]. |
| 靶点： |
GCN5/PCAF:29.04 μM (EC50);GCN5:49.31 μM (EC50);CBP:2.75 μM (EC50) |
| 体外研究： |
YF-2 (20 mg/kg, 2 hours befor electric shock or 5 mg/kg, 30 min before the electric shock, i.p.) rescues the defect in contextual memory in mice, and shows no effect on contextual memory alone at 20 mg/kg in mice[1]. |
| 体内研究： |
YF-2 (0.03, 0.1, 0.25, 0.5, 1, 2.5, 5, 15, 40 and 80 μM, 72 hours) inhibits the preliferation of U251, CCRF-CEM, Hs578T, NCI-ADR-RES cells[1]. |
| 参考文献： |
1. FENG, Yen, et al. HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF. WO 2011072243A1. |
| 保存条件： |
-80°C 6个月; -20°C 1个月, 干燥 |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
2.14 ml |
10.7 ml |
21.399 ml |
| 5 mM |
0.428 ml |
2.14 ml |
4.28 ml |
| 10 mM |
0.214 ml |
1.07 ml |
2.14 ml |
| 50 mM |
0.043 ml |
0.214 ml |
0.428 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
