货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
V57159-1ml	10mM in DMSO	￥1040.00 V57159-1ml ￥1040.00 3-5天	0 货期：3-5天	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

V57159-1ml

10mM in DMSO

￥1040.00

货期：3-5天

产品描述：

Lixumistat (HL271) hydrochloride (IM156 hydrochloride; HL156A hydrochloride), a chemical derivative of Metformin , is a potent AMPK activator that increases AMPK phosphorylation. Lixumistat hydrochloride attenuates aging-associated cognitive impairment in animal model. Lixumistat hydrochloride is a potent oxidative phosphorylation (OXPHOS) inhibitor which can be used for the research of solid tumors.

靶点：

AMPK, OXPHOS

体外研究：

Lixumistat (hydrochloride) does not affect metabolic regulation assessed by body weight, blood glucose, insulin levels and lipid metabolite content in mice with diet-induced obesity[1].
Lixumistat (hydrochloride) (50 mg/kg; for 2 months) does not affect body weight, general locomotion, or anxiety[2].
Lixumistat (hydrochloride) significantly attenuates the aging-induced decline in novel object recognition memory and spatial working memory[2].
Lixumistat (hydrochloride) significantly increases AMPK activation in the hippocampus of aged mice[2].

体内研究：

Lixumistat hydrochloride (0.31-10 μM) phosphorylates AMPKα1 Thr172 in a dose- and time-dependent manner in NIH3T3 mouse fibroblast cells.
Lixumistat hydrochloride does not affect the expression of key factors involved in glucose homeostasis such as glucose-6-phosphatase (G6pase) or phosphoenolpyruvate carboxykinase 1 (Pck1).

参考文献：

1. Row H, et al. HL271, a novel chemical compound derived from metformin, differs from metformin in its effects on the circadian clock and metabolism. Biochem Biophys Res Commun. 2016 Jan 15;469(3):783-9.
2. Bang E, et al. The Improving Effect of HL271, a Chemical Derivative of Metformin, a Popular Drug for Type II Diabetes Mellitus, on Aging-induced Cognitive Decline. Exp Neurobiol. 2018 Feb;27(1):45-56.
3. Sun Young Rha, et al. Phase I study of IM156, a novel potent biguanide oxidative phosphorylation (OXPHOS) inhibitor, in patients with advanced solid tumors. Journal of Clinical Oncology 38(15_suppl):3590-3590.

保存条件：

-80°C 6个月; -20°C 1个月, 干燥

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.843 ml	14.214 ml	28.428 ml
5 mM	0.569 ml	2.843 ml	5.686 ml
10 mM	0.284 ml	1.421 ml	2.843 ml
50 mM	0.057 ml	0.284 ml	0.569 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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