货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
V57186-1ml	10mM in DMSO	￥5920.00 V57186-1ml ￥5920.00 3-5天	0 货期：3-5天	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

V57186-1ml

10mM in DMSO

￥5920.00

货期：3-5天

产品描述：

FK706 is a potent, slow-binding and competitive inhibitor of human neutrophil elastase with an IC50 of 83 nM and a Ki of 4.2 nM. FK706 also inhibits mouse neutrophil elastase and porcine pancreatic elastase with IC50s of 22 nM and 100 nM, respectively, and has no inhibitory activity against other serine proteinases such as human pancreatic trypsin, human pancreatic α-chymotrypsin and human leukocyte cathepsin G. FK706 has anti-inflammatory effect.

体外研究：

FK706 (10-100 mg/kg; subcutaneous injection; for 1-6 hours; male C57BL mice) treatment significantly suppresses human neutrophil elastase (20 μg/paw)-induced paw edema in mice in a dose-dependent manner (47% inhibition at a dose of 100 mg/kg)[1].

体内研究：

FK706 effectively inhibits the hydrolysis of bovine neck ligament elastin (2 mg/mL final concentration) by human neutrophil elastase (4 μg/mL final concentration) with an IC50 value of 230 nM.
FK706 blocks the release of inflammatory chemokines, suppresses the expression of IL-8 and MCP-1 mRNA, and suppresses NF-κB activation. It seems possible that FK706 may directly blocks human lung fibroblasts activation of NF-κB, preventing expression of inflammatory chemokines during cigarette smoke–induced lung inflammation.

保存条件：

-80°C 12个月; -20°C 6个月, 干燥

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.688 ml	8.438 ml	16.876 ml
5 mM	0.338 ml	1.688 ml	3.375 ml
10 mM	0.169 ml	0.844 ml	1.688 ml
50 mM	0.034 ml	0.169 ml	0.338 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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