MMV008138 is a species-selective IspD (enzyme 2-C-methyl-d-erythritol 4-phosphate cytidylyltransferase)-targeting antimalarial agent, with an IC50 of 44 nM for PfIspD (P. falciparum IspD). MMV008138 inhibits the growth of P. falciparum Dd2 strain with an IC50 of 250 nM.
靶点:
Plasmodium
体内研究:
MMV008138 targets the enzyme IspD in the MEP pathway of P. falciparum. MMV008138 does not target human IspD.