| 产品描述: | Fosgonimeton (ATH-1017) is a hepatocyte growth factor receptor (c-Met/HGFR) agonist. Fosgonimeton has neuroprotective effects in both LPS -induced neuroinflammation and Aβ-induced AD models[1][2][3][4]. |
| 体外研究: |
Fosgonimeton 是一种肝细肌生长因子受体激动剂。 |
| 参考文献: |
1. Reda S, et al. Fosgonimeton, a novel, small molecule positive modulator of the HGF/MET system is neuroprotective in primary neuron culture. Alzheimer's Dement. 2022 18: e065874. 2. Reda SM, et al. Fosgonimeton attenuates amyloid-beta toxicity in preclinical models of Alzheimer's disease. Neurotherapeutics. 2024 Jul;21(4):e00350. 3. Johnston JL, et al. Fosgonimeton, a Novel Positive Modulator of the HGF/MET System, Promotes Neurotrophic and Procognitive Effects in Models of Dementia. Neurotherapeutics. 2023 Mar;20(2):431-451. 4. Leen H. KAWAS, et al. WO2017210489. 2021. |
| 保存条件: |
-80°C 6个月; -20°C 1个月,避光,氮气保存 |
| 配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
| 1 mM |
1.71 ml |
8.552 ml |
17.105 ml |
| 5 mM |
0.342 ml |
1.71 ml |
3.421 ml |
| 10 mM |
0.171 ml |
0.855 ml |
1.71 ml |
| 50 mM |
0.034 ml |
0.171 ml |
0.342 ml |
|
| 注意: |
部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。 |