货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
V57555-1ml	10mM in DMSO	￥3130.00 V57555-1ml ￥3130.00 3-5天	0 货期：3-5天	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

V57555-1ml

10mM in DMSO

￥3130.00

货期：3-5天

产品描述：

EPI-7170, a ralaniten analogue, is a potent androgen receptor N-terminal structural domain antagonist that blocks the transcriptional activity of full-length AR (FL-AR) and AR splice variants (AR-Vs). EPI-7170 has antitumor effects against enzalutamide resistant castration-resistant prostate cancer (CRPC).

体外研究：

EPI-7170 (oral administration, 30 mg/kg, daily, 31 days) has some anti-tumor activity and can be combined with enzalutamide in male NOD/SCID mice.

体内研究：

EPI-7170 (0-12 μM, 24 or 48 h) inhibits cell proliferation in VCaP-ENZR and C4-2B-ENZR cells, also enhances the effect of enzalutamide which has a lower IC 50 when bound to EPI-7170.
EPI-7170 (0-20 μM, 24 or 48 h) synergistically inhibits androgen receptor (AR) transcriptional activity in ENZR cells expressing androgen receptor splice variant-7 (AR-V7) with enzalutamide.
EPI-7170 (3.5 μM, 48 h) results in an increase in G1 phase and a decrease in S phase, and reduces the expression levels of CDK4, cyclin D1 and cyclin A2 proteins.

参考文献：

1. Hirayama Y, et al. Combination therapy with androgen receptor N-terminal domain antagonist EPI-7170 and enzalutamide yields synergistic activity in AR-V7-positive prostate cancer. Mol Oncol. 2020 Oct;14(10):2455-2470.

保存条件：

-80°C 12个月; -20°C 6个月, 干燥

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.849 ml	9.244 ml	18.488 ml
5 mM	0.37 ml	1.849 ml	3.698 ml
10 mM	0.185 ml	0.924 ml	1.849 ml
50 mM	0.037 ml	0.185 ml	0.37 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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