DS28120313 (compound 32) is an orally hepcidin production inhibitor with an IC50 of 0.093 μM.
体外研究:
DS28120313 (deliver orally; 30 mg/kg; 30 min before IL-6 administration) inhibits hepcidin production and reduces the blood hepcidin level in IL-6 induced acute inflammatory C57BL/6 mouse model[1].