Inupadenant is an orally active, highly selective A2A receptor antagonist. Inupadenant can not cross BBB. Inupadenant can enhance the humoral immune response and has anti-tumor activity.
体外研究:
Inupadenant 在 CT 26-OVA 小鼠中,可增加血液和肿瘤中 OVA 特异性 IgG,以及脾脏和肿瘤中的 B 细胞和抗体分泌细胞[2]。