| 产品描述： | MeOIstPyrd is an anti-skin cancer agent. MeOIstPyrd inhibits cell proliferation, migration, and spheroid formation by activating the mitochondrial intrinsic apoptotic pathway. MeOIstPyrd induces DNA damage. MeOIstPyrd activates p53, and increases the half-life of p53 and stabilizes p53 by phosphorylating it at ser15. MeOIstPyrd binds to MDM2 in the p53 sub-pocket and blocks p53-MDM2 interaction. |
| 参考文献： |
1. Nerina Shahi, et al. 5-Methoxyisatin N(4)-Pyrrolidinyl Thiosemicarbazone (MeOIstPyrd) Restores Mutant p53 and Inhibits the Growth of Skin Cancer Cells, In Vitro. https://pubs.acs.org/doi/10.1021/acsomega.3c03824. ACS Omega 2023, 8, 35, 31998鈥?2016. |
| 保存条件： |
-80°C 6个月; -20°C 1个月,避光 |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
3.285 ml |
16.427 ml |
32.855 ml |
| 5 mM |
0.657 ml |
3.285 ml |
6.571 ml |
| 10 mM |
0.329 ml |
1.643 ml |
3.285 ml |
| 50 mM |
0.066 ml |
0.329 ml |
0.657 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京