(7S)-BAY-593 is the S-enantiomer of BAY-593 . BAY-593 is an orally active GGTase-I inhibitor. BAY-593 can block YAP1/TAZ signaling in animals and has antitumor activity.
参考文献:
1. Graham K, et al. Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling. Cell Chem Biol. 2024 Mar 19:S2451-9456(24)00087-4.