(Rac)-Cemsidomide ((Rac)-CFT7455) is the racemate of Cemsidomide with antitumor activity. Cemsidomide is a ubiquitin ligase pathway Ikaros/Aiolos degrader with molecular glue activity. Cemsidomide has a GI50 of 0.05 nM for NCIH929.1 cells.
靶点:
Ikaros, Aiolos
参考文献:
1. David Proia et al. Advantageous therapies for disorders mediated by ikaros or aiolos. WO2022032132A1 (compound 5)