| 产品描述： | AE-3763 is a peptide-based human neutrophil elastase inhibitor with an IC50 of 29 nM. |
| 体外研究： |
Edema and leukocytes infiltration into the lung are significantly inhibited by infusion of AE-3763. AE3763 significantly improves survival rate by 24 h in a mouse model of fatal shock associated with multiple organ dysfunction. AE-3763 dose-dependently prevents hemorrhage when given intravenously by infusion (ED50: 0.42 mg/kg/h) or by bolus injection (1.2 mg/kg). With regard to the toxicity of AE-3763 in mice, the results of a preliminary study have shown no overt toxic effect even at the high dose of 300 mg/kg, iv[1]. |
| 体内研究： |
AE-3763 exhibits potent in vitro inhibitory activity against human neutrophil elastase as well as extremely high solubility and stability in water. |
| 保存条件： |
-80°C 6个月;-20°C 1个月 |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
1.82 ml |
9.099 ml |
18.197 ml |
| 5 mM |
0.364 ml |
1.82 ml |
3.639 ml |
| 10 mM |
0.182 ml |
0.91 ml |
1.82 ml |
| 50 mM |
0.036 ml |
0.182 ml |
0.364 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京