| 产品描述： | BMS-770767 is an 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitor in type 2 diabetes. 11β-HSD1 is an important enzyme that is widely expressed in liver, adipose tissue and other tissues and plays an important role in metabolic diseases such as diabetes and obesity. |
| 靶点： |
Alpha-2A adrenergic receptor:0.23 nM (EC50); Alpha-1A adrenergic receptor:2.5 nM (EC50); Alpha-2B adrenergic receptor:16.3 nM (EC50) |
| 参考文献： |
1. Lv X, et al., Designing Chromane Derivatives as α2A-Adrenoceptor Selective Agonists via Conformation Constraint. J Med Chem. 2024 Jun 18.
|
| 保存条件： |
-80°C 6个月;-20°C 1个月 |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
3.583 ml |
17.913 ml |
35.826 ml |
| 5 mM |
0.717 ml |
3.583 ml |
7.165 ml |
| 10 mM |
0.358 ml |
1.791 ml |
3.583 ml |
| 50 mM |
0.072 ml |
0.358 ml |
0.717 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
