货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
V58345-1ml	10mM in DMSO	￥3100.00 V58345-1ml ￥3100.00 3-5天	0 货期：3-5天	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

V58345-1ml

10mM in DMSO

￥3100.00

货期：3-5天

产品描述：

Hcyb1 is a highly selective, orally active PDE2 inhibitor. Hcyb1 has a highly selective inhibition of PDE2A (IC50=0.57 μM) and over 250-fold selectivity against other recombinant PDE family members. Hcyb1 produces neuroprotective and antidepressant‐like effects most likely mediated by cAMP/cGMP-CREB-BDNF signaling.

靶点：

PDE2

体外研究：

Hcyb1 (0.5, 1, and 2 mg/kg, i.g.) decreases the immobility time in both forced swimming and tail suspension tests, without altering locomotor activity.

体内研究：

Hcyb1 (1~100 nM; 10 minutes) increases cGMP levels by 1.7~2.3 folds.
Hcyb1 (1 nM; 24 hours) increases both cGMP and cAMP levels.
Hcyb1 (24 hours) treatment also increases the levels of phosphorylation of CREB and BDNF in HT-22 cells.
Hcyb1 promotes HT-22 cell viability and increase the cGMP and cAMP accumulation in HT-22 cells.
Hcyb1 exhibits the concentration- and time-dependent effects on cell viability in HT-22 cells.

保存条件：

-80°C 6个月;-20°C 1个月

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.629 ml	13.143 ml	26.285 ml
5 mM	0.526 ml	2.629 ml	5.257 ml
10 mM	0.263 ml	1.314 ml	2.629 ml
50 mM	0.053 ml	0.263 ml	0.526 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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