货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
V58394-1ml	10mM in DMSO	￥3270.00 V58394-1ml ￥3270.00 3-5天	0 货期：3-5天	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

V58394-1ml

10mM in DMSO

￥3270.00

货期：3-5天

产品描述：

TH-6 is a potent HDAC inhibitor with IC50s of 0.115, 0.135, 0.242, 0.138, 2.120 µM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, respectively. TH-6 inhibits cell migration and invasion. TH-6 induces apoptosis and cell cycle arrest at G2/M phase. TH-6 shows anti-tumor activity.

靶点：

HDAC1:0.115 μM (IC50); HDAC2:0.135 μM (IC50); HDAC3:0.242 μM (IC50); HDAC6:0.138 μM (IC50); HDAC8:2.120 μM (IC50)

体外研究：

TH-6 (10, 20 mg/kg; i.v.; daily for 21 days) shows anti-tumor activity in mouse.
TH-6 (20 mg/kg) shows antivascular activity and a good cardiovascular safety profile in mouse.

体内研究：

TH-6 (0-2 µM) shows antiproliferative activities in cancer cell lines and normal human lung cells.
TH-6 (0-10 µM) inhibits tubulin polymerization with an IC50 value of 4.06 µM.
TH-6 (0.03, 0.1, 0.3 1 µM; 24 h) increases the expression of Ac-α-Tubulin and AC-Histone H3 in HepG2 cells.
TH-6 (7.5, 15, 30 nM) induces apoptosis and cell cycle arrest at G2/M phase.
TH-6 (0-30 nM) decreases the MMP and increase ROS levels of HepG2 cells in a dose-dependent manner.
TH-6 (7.5, 15, 30 nM; 48 h) inhibits cell migration and invasion in MDA-MB-231 cells and suppress the migration of HUVECs in a concentration-dependent manner.
TH-6 shows favorable liver microsomal stability in vitro with t1/2 of 50.3 min.

参考文献：

1. Zhu H, et al. Discovery of a Novel Vascular Disrupting Agent Inhibiting Tubulin Polymerization and HDACs with Potent Antitumor Effects. J Med Chem. 2022 Aug 4.

保存条件：

-80°C 6个月; -20°C 1个月,避光

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.329 ml	11.643 ml	23.286 ml
5 mM	0.466 ml	2.329 ml	4.657 ml
10 mM	0.233 ml	1.164 ml	2.329 ml
50 mM	0.047 ml	0.233 ml	0.466 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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