货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
V58421-1ml	10mM in DMSO	￥1100.00 V58421-1ml ￥1100.00 3-5天	0 货期：3-5天	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

V58421-1ml

10mM in DMSO

￥1100.00

货期：3-5天

产品描述：

Nrf2-ARE/hMAO-B/QR2 modulator 1 is a Resveratrol-based multitarget-directed ligands with IC50s of 8.05, 9.83 and 0.57 μM for hMAO-B, NRF2 and QR2. Nrf2-ARE/hMAO-B/QR2 modulator 1 has neuroprotection, decreasing ROS production in okadaic acid-treated mice hippocampal slices. Nrf2-ARE/hMAO-B/QR2 modulator 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

靶点：

IC50: 8.05 μM (hMAO-B), 9.83 μM (NRF2), 0.57 μM (QR2)

体内研究：

Nrf2-ARE/hMAO-B/QR2 modulator 1 (compound 4e) (100 μM; 24 hours) reduces the viability of SH-SY5Y cells by around 30%.
Nrf2-ARE/hMAO-B/QR2 modulator 1 (1 μM; 24 hours for pre-treatment, then coincubated for another 24 hours with 10 nM okadaic acid (OA)) significantly increases the cell viability of OA-treated rat primary cortical neurons to 70-80%.
Nrf2-ARE/hMAO-B/QR2 modulator 1 (10 μM) shows the highest expression of young cells (TuJ-1) and mature neurons (MAP-2), as well as the greatest distance of cell migration in mice NSCs which isolated from SGZ.
Nrf2-ARE/hMAO-B/QR2 modulator 1 (1 μM; 72 hours) confers neuroprotection and reduces cell death, decreasing ROS production in mice hippocampal slices exposed to OA.

参考文献：

1. Herrera-Arozamena C, Estrada-Valencia M, López-Caballero P, et al. Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades. J Med Chem. 2022;65(6):4727-4751.

保存条件：

-80°C 6个月; -20°C 1个月,避光

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.902 ml	19.511 ml	39.023 ml
5 mM	0.78 ml	3.902 ml	7.805 ml
10 mM	0.39 ml	1.951 ml	3.902 ml
50 mM	0.078 ml	0.39 ml	0.78 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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