cis-KV1.3-IN-1 (Compound cis-18) is a cis-isomer of KV1.3-IN-1 . cis-KV1.3-IN-1 is an inhibitor of the KV1.3 channel. cis-KV1.3-IN-1 (10 μM) inhibits KV1.3 by 25.53% in Xenopus oocytes expressing human hKV1.3.
参考文献:
1. Gubič Š, et al. Immunosuppressive effects of new thiophene-based KV1.3 inhibitors. Eur J Med Chem. 2023 Jun 25;259:115561.