| 产品描述: | PRRSV/CD163-IN-1 is a PRRSV/CD163 inhibitor. PRRSV/CD163-IN-1 can inhibit the interaction between the PRRSV glycoprotein (GP2a or GP4) and the CD163-SRCR5 domain. PRRSV/CD163-IN-1 can be used for the research of porcine reproductive and respiratory syndrome (PRRS) . |
| 体内研究: |
PRRSV/CD163-IN-1 (Compound B7) (5 μM) inhibits the Protein-protein interaction (PPI) between PRRSV GP4 glycoprotein and CD163-SRCR5 domain. PRRSV/CD163-IN-1 (24 h) is well-tolerated by PAMs at concentrations below 25 μM, with the LC50 value of 81.7 μM. PRRSV/CD163-IN-1 (0, 5, 10, 15, or 20 μM; 4 h) inhibits PRRSV infection of PAMs in a dose-dependent manner. PRRSV/CD163-IN-1 (15 μM) significantly inhibits the infection caused by both type I and type II PRRSV strains. |
| 参考文献: |
1. Chang Huang, et al. Small molecules block the interaction between porcine reproductive and respiratory syndrome virus and CD163 receptor and the infection of pig cells. Virol J. 2020 Jul 30;17(1):116 |
| 保存条件: |
-80°C 6个月;-20°C 1个月 |
| 配置溶液浓度参考: |
|
1mg |
5mg |
10mg |
| 1 mM |
1.793 ml |
8.967 ml |
17.933 ml |
| 5 mM |
0.359 ml |
1.793 ml |
3.587 ml |
| 10 mM |
0.179 ml |
0.897 ml |
1.793 ml |
| 50 mM |
0.036 ml |
0.179 ml |
0.359 ml |
|
| 注意: |
部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。 |