MB-07344 is a potent thyroid hormone receptor (TR)-β agonist with a Ki of 2.17 nM. MB-07344 has additive cholesterol lowering activity in combination with Atorvastatin in rabbits, dogs and monkeys.
体外研究:
MB-07344 (0.05 mg/kg; i.v.; 3 times per week for 3 weeks) results in adjunctive and additive activity when given in combination with Atorvastatin in normal rabbits[1].