货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
V58675-1ml	10mM in DMSO	￥3650.00 V58675-1ml ￥3650.00 3-5天	0 货期：3-5天	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

V58675-1ml

10mM in DMSO

￥3650.00

货期：3-5天

产品描述：

A3051 is a potent and orally active inhibtor of CXXC5-DVL extracted from patent WO2020079569, has an IC50 of 63.06 nM. A3334 can be used for the research of high fat diet (HFD)-induced and methionine-choline deficient diet (MCD)-induced phenotypes such as obesity, diabetes, and NASH.

体外研究：

A3334 (25 mg/kg; p.o. once daily for 16 weeks) has anti-obesity effects in the HFD mice, and has no effect on mice fed with normal diet.
A3334 (25 mg/kg; p.o. once daily for 5 days) significantly reduces fasting glucose and the levels of glucose tolerance (GTT) and insulin tolerance (ITT) in serum in mice.
A3334 (25 mg/kg; p.o. once daily for 3 weeks) significantly abolishes hepatosteatosis and the increased levels of alanine transaminase (ALT) and aspartatetransaminase (AST) in mice.

体内研究：

A3334 (1-10 μM) efficiently inhibits the adipogenic differentiation of 3T3-L1 preadipocytes via the Wnt/β-eatenin signaling pathway.
A3334 (1-10 μM; 24 h) enhances the TOPFlash reporter activity in HEK293-TOP cells.

参考文献：

1. Choi KY, et, al. Compositions and methods for suppressing and/or treating metabolic diseases and/or a clinical condition thereof. WO2020079569.

保存条件：

-80°C 6个月;-20°C 1个月

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.254 ml	16.271 ml	32.541 ml
5 mM	0.651 ml	3.254 ml	6.508 ml
10 mM	0.325 ml	1.627 ml	3.254 ml
50 mM	0.065 ml	0.325 ml	0.651 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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