货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
V58730-1ml	10mM in DMSO	￥6480.00 V58730-1ml ￥6480.00 3-5天	0 货期：3-5天	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

V58730-1ml

10mM in DMSO

￥6480.00

货期：3-5天

产品描述：

S-methyl DM1 is a thiomethyl derivative of Maytansine. S-methyl DM1 binds to tubulin with a Kd of 0.93 μM and inhibts microtubule polymerization. S-methyl DM1 potently suppresses microtubule dynamic instability and has anticancer effects[1][2].

靶点：

Maytansinoids

体内研究：

S-methyl DM1 is the primary cellular or liver metabolite of antibody-maytansinoid conjugates prepared with thiol-containing maytansinoids DM1[1].
The half-maximal concentration for inhibition of microtubule assembly for for S-methyl DM1 is 4 μM. At 100 nM S-methyl-DM1 (84%) suppresses dynamic instability more strongly than Maytansine (45%). Tritiated S-methyl-DM1 bound to 37 high-affinity sites per microtubule (Kd of 0.1 μM)[1].
The concentration dependence curves for the inhibition of cell proliferation by S-methyl DM1 is sigmoidal in shape in MCF7 cells. Minimal inhibition occurred at 200 pM S-methyl DM1, and inhibition is maximal at 3 nM. S-methyl DM1 (IC50 of 330 pM) is slightly more potent than Maytansine (IC50 of 710 pM)[2].
S-methyl DM1 induces maxima of 80% accumulation of cells in G2/M as compared with only 30% in controls in MCF7 cells[2].

保存条件：

-80°C 6个月; -20°C 1个月, 干燥

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.329 ml	6.646 ml	13.292 ml
5 mM	0.266 ml	1.329 ml	2.658 ml
10 mM	0.133 ml	0.665 ml	1.329 ml
50 mM	0.027 ml	0.133 ml	0.266 ml

注意：

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参考文献

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