货号	规格	价格	上海	北京	珠海	重庆	武汉
V65559-5mg促销	≥95%	￥600.00 ￥540.00 V65559-5mg ￥540.00 现货	4 4	-	-	-	-
V65559-25mg促销	≥95%	￥1800.00 ￥1620.00 V65559-25mg ￥1620.00 现货	5 5	-	-	-	-
V65559-100mg促销	≥95%	￥5000.00 ￥4500.00 V65559-100mg ￥4500.00 现货	2 2	-	-	-	-

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体内研究：

The optimized siRNA-loaded CL4H6-LNPs are selectively and efficiently taken up and showed strong gene silencing activity in tumor-associated macrophages (TAMs) in a human tumor xenograft model in nude mice. The anti-tumor therapeutic response is obtained through the silencing of the STAT3 and HIF-1α, which resulted in an increase in the level of infiltrated macrophage (CD11b+ cells) into the tumor-microenvironment (TME) as well as a tendency to increase the concentration of M1 macrophages (CD169+ cells). The treatment also resulted in reversing the pro-tumorous functions of TAMs -mainly angiogenesis and tumor cell activation-, as evidenced by a decrease in the related gene expression at the mRNA level.

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.091 ml	5.455 ml	10.911 ml
5 mM	0.218 ml	1.091 ml	2.182 ml
10 mM	0.109 ml	0.546 ml	1.091 ml
50 mM	0.022 ml	0.109 ml	0.218 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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