货号	规格	价格	上海	北京	珠海	重庆	武汉
V70983-1mg	≥98%	￥1790.00 V70983-1mg ￥1790.00 3-5天	0 货期：3-5天	-	-	-	-
V70983-5mg	≥98%	￥3960.00 V70983-5mg ￥3960.00 3-5天	0 货期：3-5天	-	-	-	-
V70983-10mg	≥98%	￥5940.00 V70983-10mg ￥5940.00 3-5天	0 货期：3-5天	-	-	-	-

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靶点：

S1PR1:12.6-493 nM (EC50)

体内研究：

SAR247799 (1 and 3 mg/kg; p.o.; 1 h before renal occlusion) dose dependently reduces the severity of ischemia/reperfusion (I/R)–induced acute kidney injury.
SAR247799 (0.3, 1, 3 mg/kg; i.v.) dose dependently increases the coronary conductance ratio in pig model of coronary endothelial dysfunction.
SAR247799 (30-min intravenous administration; 8- to 10-week-old farm pig) exposure (Cmax and AUC) increases with dose in pigs. Pharmacokinetic parameters :

参考文献：

1. Poirier B, et al. A G protein-biased S1P1 agonist, SAR247799, protects endothelial cells without affecting lymphocyte numbers. Sci Signal. 2020 Jun 2;13(634):eaax8050.
2. Evaristi MF, et al. A G-protein-biased S1P1 agonist, SAR247799, improved LVH and diastolic function in a rat model of metabolic syndrome. PLoS One. 2022 Jan 14;17(1):e0257929.
3. Bergougnan L, et al. Endothelial-protective effects of a G-protein-biased sphingosine-1 phosphate receptor-1 agonist, SAR247799, in type-2 diabetes rats and a randomized placebo-controlled patient trial. Br J Clin Pharmacol. 2021 May;87(5):2303-2320.
4. Bergougnan L, et al. First-in-human study of the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple oral doses of SAR247799, a selective G-protein-biased sphingosine-1 phosphate receptor-1 agonist for endothelial protection

保存条件：

2-8°C,避光,RT,干燥

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.348 ml	11.742 ml	23.484 ml
5 mM	0.47 ml	2.348 ml	4.697 ml
10 mM	0.235 ml	1.174 ml	2.348 ml
50 mM	0.047 ml	0.235 ml	0.47 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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