货号	规格	价格	上海	北京	珠海	重庆	武汉
Y38928-1mg	98%	￥450.00 Y38928-1mg ￥450.00 3-5天	0 货期：3-5天	-	-	-	-
Y38928-5mg促销	99.60%	￥1310.00 ￥1040.00 Y38928-5mg ￥1040.00 现货	9 9	-	-	-	-
Y38928-10mg促销	99.60%	￥1690.00 ￥1350.00 Y38928-10mg ￥1350.00 现货	5 5	-	-	-	-
Y38928-50mg促销	99.60%	￥4030.00 ￥3220.00 Y38928-50mg ￥3220.00 现货	2 2	-	-	-	-

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靶点：

α7 nAChR

体内研究：

Encenicline (EVP-6124) has good brain penetration and an adequate exposure time. Encenicline (EVP-6124) (0.3 mg/kg, p.o.) significantly restores memory function in scopolamine-treated rats (0.1 mg/kg, i.p.) in an object recognition task (ORT). Although donepezil at 0.1 mg/kg, p.o. or Encenicline at 0.03 mg/kg, p.o. did not improve memory in this task, co-administration of these sub-efficacious doses fully restored memory. In a natural forgetting test, an ORT with a 24 h retention time, Encenicline improved memory at 0.3 mg/kg, p.o. This improvement is blocked by the selective α7 nAChR antagonist methyllycaconitine (0.3 mg/kg, i.p. or 10 μg, i.c.v.). Encenicline (EVP-6124) is found to bind moderately to rat plasma proteins with a mean fu of 0.11±0.01 (mean±SD) or 11%. Over a range of 0.1-30 mg/kg, p.o., Encenicline (EVP-6124) demonstrates proportional dose escalation. Tmax is at 4 h in plasma and 2 h brain, although the brain concentrations remained similar between 2 and 8 h. The B:P ratios are 1.7-5.1 between 1 and 8 h. Pharmacokinetic studies have shown that Encenicline (EVP-6124) (0.4 mg/kg, i.p.) reaches peak brain concentration 2 hr after administration and remains at effective concentrations for at least 4 hr. Encenicline (EVP-6124) is administered to WT mice at ZT0 (0.4 mg/kg i.p single dose) and significantly increases the saturation index of NMDARs in slices obtained 4 hr later without causing prolonged wakefulness or enhanced locomotor activity .

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	3.117 ml	15.584 ml	31.168 ml
5 mM	0.623 ml	3.117 ml	6.234 ml
10 mM	0.312 ml	1.558 ml	3.117 ml
50 mM	0.062 ml	0.312 ml	0.623 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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分子摩尔量

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