货号	规格	价格	上海	北京	珠海	重庆	武汉	购买数量
Y40191-100mg	99.40%	￥385.00 Y40191-100mg ￥385.00 现货	2 2	-	-	-	-
Y40191-500mg促销	99.40%	￥1610.00 ￥1500.00 Y40191-500mg ￥1500.00 现货	3 3	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

Y40191-100mg

99.40%

￥385.00

Y40191-500mg促销

99.40%

￥1610.00 ￥1500.00

产品描述：

Naphtofluorescein is a pH-sensitive fluorescent probe, also used for preparation of labels and enzyme substrates.

靶点：

HIF-1

体内研究：

Naphthofluorescein (compound 19) (100 mg/kg; i.p.; once daily for 5 consecutive days followed by 2 days off for 2 weeks)does not show weight loss or apparent histological abnormalities in the lung, liver, and kidney, or cause cause severe adverse effects for at least 2 weeks in mice.
Naphthofluorescein (compound 19) (100 mg/kg; i.p.; once daily for 5 consecutive days followed by 2 days off for 2 weeks) strikingly suppresses the tumour growth of subcutaneously injected E0771 cells and significantly attenuates tumour growth of MDA-MB-231 and AsPC-1 cells in immunodeficient mice. In turn, naphthofluorescein does not attenuate tumour growth of FIH-1-depleted MDA-MB-231 cells.
Naphthofluorescein (compound 19) (100 mg/kg; i.p.; once daily for 5 consecutive days followed by 2 days off for 2 weeks) suppresses tumour growth in human cancer cells in an FIH-1-dependent manner.

参考文献：

1. Sakamoto T, et al. Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock. Commun Biol. 2021;4(1):1165. Published 2021 Oct 7.
2. Arroyo AD, et al. Development of fluorinated naphthofluoresceins for Cerenkov imaging. J Fluor Chem. 2019;225:27-34.

保存条件：

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.313 ml	11.563 ml	23.126 ml
5 mM	0.463 ml	2.313 ml	4.625 ml
10 mM	0.231 ml	1.156 ml	2.313 ml
50 mM	0.046 ml	0.231 ml	0.463 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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