货号	规格	价格	上海	北京	珠海	重庆	武汉
Y45163-1mg	97%	￥290.00 Y45163-1mg ￥290.00 3-5天	0 货期：3-5天	-	-	-	-
Y45163-5mg	97%	￥850.00 Y45163-5mg ￥850.00 3-5天	0 货期：3-5天	-	-	-	-
Y45163-100mg	97%	￥5800.00 Y45163-100mg ￥5800.00 3-5天	0 货期：3-5天	-	-	-	-

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靶点：

EC50: 27.3 pM (hS1P1), 334 pM (hS1P5).

体内研究：

The clinical scores of the Ceralifimod (ONO-4641) 0.03 and 0.1 mg/kg groups remain lower than that in the control group. The maximum clinical scores decrease dose-dependently in the Ceralifimod (ONO-4641) groups and those in the Ceralifimod (ONO-4641) 0.03 and 0.1 mg/kg groups are significantly lower than that in the control group. Specifically, paralysis is inhibited completely in seven of eight animals in the Ceralifimod (ONO-4641) 0.1 mg/kg group.
In normal NOD mice, the number of peripheral blood lymphocytes is decreased by approximately 20, 60 and 80% at 24 h after a single oral dose of 0.01, 0.03 and 0.1 mg/kg of Ceralifimod (ONO-4641), respectively. In the control group of the NOD mouse model of relapsing-remitting EAE, the relapse rate is 90.0%, and two of the nine animals die. The cumulative clinical score in the control group is 65.4±18.50. In contrast, none of animals in the Ceralifimod (ONO-4641) 0.1 mg/kg group have a relapse; that is, Ceralifimod completely prevents relapse at a dose of 0.1 mg/kg. In the Ceralifimod (ONO-4641) groups, two of the nine animals in the 0.01 mg/kg die.

保存条件：

2-8℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.296 ml	11.48 ml	22.959 ml
5 mM	0.459 ml	2.296 ml	4.592 ml
10 mM	0.23 ml	1.148 ml	2.296 ml
50 mM	0.046 ml	0.23 ml	0.459 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

质量

浓度

体积

分子摩尔量

计算重置

ceralifimod