货号	规格	价格	上海	北京	珠海	重庆	武汉
Y63849-5mg买3赠1	99.67%	￥510.00 Y63849-5mg ￥510.00 现货（买3赠1）	6 6	-	-	-	-
Y63849-10mg买3赠1	99.67%	￥850.00 Y63849-10mg ￥850.00 现货（买3赠1）	5 5	-	-	-	-
Y63849-25mg	99.67%	￥1830.00 Y63849-25mg ￥1830.00 现货	4 4	-	-	-	-
Y63849-100mg	99.67%	￥4350.00 Y63849-100mg ￥4350.00 现货	1 1	-	-	-	-

货号

规格

价格

上海

北京

珠海

重庆

武汉

购买数量

Y63849-5mg买3赠1

99.67%

￥510.00

Y63849-10mg买3赠1

99.67%

￥850.00

Y63849-25mg

99.67%

￥1830.00

Y63849-100mg

99.67%

￥4350.00

产品描述：

8-Bromo-cGMP sodium, a membrane-permeable analogue of cGMP, is a PKG (protein kinase G) activator. 8-Bromo-cGMP sodium significantly inhibits Ca2+ macroscopic currents and impairs insulin release stimulated with high K+. 8-Bromo-cGMP sodium has antinociceptive effects and results in vasodilator responses

靶点：

Calcium Channel;CalciumChannel; PKA

体外研究：

8-Bromo-cGMP sodium (1-100 μM; 8 h) increases resistance of LLC-PK1 cells to CsA toxicity concentration-dependently. 8-Bromo-cGMP sodium (1-100 μM; 16 h) induces the synthesis of HO-1 protein in a concentration-dependent fashion. Cell Viability Assay Cell Line: LLC-PK1 cells (ATCC CL 101) Concentration: 1-100 μM Incubation Time: 8 hours Result: Increased resistance of LLC-PK1 cells to Cyclosporin A (CsA) toxicity concentration-dependently and augmented cell viability by up to 65%. Western Blot Analysis Cell Line: LLC-PK1 cells (ATCC CL 101) Concentration: 1-100 μM Incubation Time: 16 hours Result: Induced the synthesis of HO-1 protein in a concentration-dependent fashion.

体内研究：

8-Bromo-cGMP sodium (0.3, 1, 3.0 nmol; intrathecal administration; 10 min before test) dose-dependently and significantly increases the tail-flick latency in Vincristine-treated mice to the level observed in vehicle-treated naive mice (male ICR mice, 4weeks of age and weighing 20 g). Vincristine (0.05 mg/kg 1 day after the pre-drug tail-flick latency, and then 0.125 mg/kg twice a week for 6 weeks) can induce painful neuropathy in mice. 8-Bromo-cGMP sodium (10 mg/kg; iv; single dose) results in vasodilator responses in eNOS-Tg mice and WT littermates in C57BL/6 background (19-35 g).

参考文献：

1. Sarkar O , et al. Nitric oxide attenuates overexpression of Giα proteins in vascular smooth muscle cells from SHR: Role of ROS and ROS-mediated signaling. PLoS One. 2017 Jul 10;12(7):e0179301. 2. Tegeder I , et al. Dual effects of spinally delivered 8-bromo-cyclic guanosine mono-phosphate (8-bromo-cGMP) in formalin-induced nociception in rats. Neurosci Lett. 2002 Oct 31;332(2):146-50. 3. Tobias Polte, et al. Atrial natriuretic peptide reduces cyclosporin toxicity in renal cells: role of cGMP and heme oxygenase-1. Free Radic Biol Med. 2002 Jan 1;32(1):56-63. 4. Junzo Kamei, et al. Possible involvement of the spinal nitric oxide/cGMP pathway in vincristine-induced painful neuropathy in mice. Pain. 2005 Sep;117(1-2):112-20. 5. Elza D van Deel, et al. Vasomotor control in mice overexpressing human endothelial nitric oxide synthase. Am J Physiol Heart Circ Physiol. 2007 Aug;293(2):H1144-53.

溶解性：

Soluble in H2O

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.242 ml	11.209 ml	22.418 ml
5 mM	0.448 ml	2.242 ml	4.484 ml
10 mM	0.224 ml	1.121 ml	2.242 ml
50 mM	0.045 ml	0.224 ml	0.448 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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