货号	规格	价格	上海	北京	武汉	南京	购买数量
B50736-20mg	分析标准品,HPLC≥98%	￥200.00 B50736-20mg ￥200.00 现货	130 5 >10	2	-	3
B50736-100mg	分析标准品,HPLC≥98%	￥600.00 B50736-100mg ￥600.00 现货	27 >10	-	-	-

产品介绍

Gefitinib (ZD1839) 是一种有效，选择性和口服活性的 EGFR 酪氨酸激酶抑制剂，IC50 为 33 nM。Gefitinib 选择性抑制 EGF 刺激的肿瘤细胞生长 (IC50 为 54 nM)，并阻断 EGF 刺激的肿瘤细胞中 EGFR 自磷酸化。Gefitinib 还可诱导细胞自噬 (autophagy) 和凋亡 (apoptosis)，可用于癌症相关的研究，如肺癌和乳腺癌。

熔点：	119-120℃
沸点：	586.8℃
外观：	白色至米黄色粉末
溶解性：	DMSO : 125 mg/mL (279.70 mM; Need ultrasonic)
储存条件：	-20℃
用途：	An EGFR-tyrosine kinase inhibitor
注意：	部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献(17篇)

17. [IF=2.6] Shihui Xie et al."Bee venom prompts the inhibition of gefitinib on proliferation, migration, and invasion of non-small cell lung cancer cells via EGFR-mediated autophagy."TOXICON.2024 Nov;251:108149 16. [IF=3.2] Chen Bu et al."LC-MS/MS method for quantification of 23 TKIs in Plasma: Assessing the relationship between anlotinib trough concentration and toxicities."CLINICA CHIMICA ACTA.2024 Nov;:120028 15. [IF=8.3] Kaiyong Yang et al."CRISPR-dCas9-Mediated PTEN Activation via Tumor Cell Membrane-Coated Nanoplatform Enhances Sensitivity to Tyrosine Kinase Inhibitors in Nonsmall Cell Lung Cancer."ACS Applied Materials & Interfaces.2025;XXXX(XXX):XXX-XXX 14. [IF=3.5] Xiaowen Wang et al."Targeted degradation of KRAS protein in non-small cell lung cancer: Therapeutic strategies using liposomal PROTACs with enhanced cellular uptake and pharmacokinetic profiles."DRUG DEVELOPMENT RESEARCH.2024 Aug;85(5):e22241 13. [IF=5.1] Hongyan Lin et al."Modified Podophyllotoxin Phenoxyacetamide Phenylacetate Derivatives: Tubulin/AKT1 Dual-Targeting and Potential Anticancer Agents for Human NSCLC."JOURNAL OF NATURAL PRODUCTS.2023;XXXX(XXX):XXX-XXX

12. [IF=5.988] Wen Jiang et al."Rapid Determination of 9 Tyrosine Kinase Inhibitors for the Treatment of Hepatocellular Carcinoma in Human Plasma by QuEChERS-UPLC-MS/MS."Frontiers in Pharmacology.2022; 13: 920436 11. [IF=5.34] Hai-Qiao Wang et al."Schisandrin B targets cannabinoid 2 receptor in Kupffer cell to ameliorate CCl4-induced liver fibrosis by suppressing NF-κB and p38 MAPK pathway."Phytomedicine. 2022 Apr;98:153960 10. [IF=4.207] Jianghua Ding et al."LPCAT1 promotes gefitinib resistance via upregulation of the EGFR/PI3K/AKT signaling pathway in lung adenocarcinoma."J Cancer. 2022; 13(6): 1837–1847 9. [IF=4.759] Zhihua Song et al."Synthesis and evaluation of fosfomycin group end-capped packing materials for hydrophilic interaction liquid chromatography."J Chromatogr A. 2021 Oct;1656:462529 8. [IF=11.413] Yanqiu Gu et al."Development of 3-mercaptopropyltrimethoxysilane (MPTS)-modified bone marrow mononuclear cell membrane chromatography for screening anti-osteoporosis components from Scutellariae Radix."Acta Pharm Sin B. 2020 Oct;10:1856 7. [IF=3.935] Yanqiu Gu et al."Comparative two-dimensional HepG2 and L02/ cell membrane chromatography/ C18/ time-of-flight mass spectrometry for screening selective anti-hepatoma components from Scutellariae Radix."J Pharmaceut Biomed. 2019 Feb;164:550 6. Gu, Yanqiu, et al. "Development of 3-mercaptopropyltrimethoxysilane (MPTS)-modified bone marrow mononuclear cell membrane chromatography for screening anti-osteoporosis components from Scutellariae Radix." Acta Pharmaceutica Sinica B 10.10 (2020): 1856-186 5. Lin, Qing, et al. "Design of gefitinib-loaded poly (l-lactic acid) microspheres via a supercritical anti-solvent process for dry powder inhalation." International journal of pharmaceutics 532.1 (2017): 573-580.https://doi.org/10.1016/j.ijpharm.2017.09.051 4. Yanqiu, et al. "Comparative two-dimensional HepG2 and L02/ cell membrane chromatography/ C18/ time-of-flight mass spectrometry for screening selective anti-hepatoma components from Scutellariae Radix. " Journal of pharmaceutical and biomedical analysis 164 3. 吕昕,朱渊红,周林水,王真,刘正中.白花蛇舌草乙醇提取物联合吉非替尼对TGF-β_1诱导的肺腺癌细胞H358上皮间质化的干预作用[J].中国现代应用药学,2016,33(02):154-158. 2. 陈芝, 俞建东, 唐超园,等. 榄香烯注射液对吉非替尼在PC-9/GR细胞内转运动力学影响[J]. 中成药, 2018, 40(002):284-290. 1. 吕昕周林水陈瑞琳等. shRNA干扰TTF-1基因对肺腺癌细胞EGFR-TKI敏感性及细胞上皮间质化的影响[J]. 浙江医学 2019 v.41(22):28-32+108.

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