Sorafenib

    
分析标准品,HPLC≥98%

Sorafenib

源叶
B50749 一键复制产品信息
284461-73-0
C21H16ClF3N4O3
464.83
Nexavar;Bay 43-9006;索拉非尼;4-{4-[3-(4-氯-3-三氟甲基苯基)酰脲]苯氧基}吡啶-2-甲酰胺;Raf抑制剂
货号 规格 价格 上海 北京 武汉 南京 购买数量
B50749-20mg 分析标准品,HPLC≥98% ¥298.00 >10 - - -
B50749-50mg 分析标准品,HPLC≥98% ¥600.00 4 - - -
产品介绍 参考文献(17篇) 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

Sorafenib是Raf-1, B-Raf和VEGFR-2的多重激酶抑制剂,IC50分别为6 nM, 22 nM和90 nM。还能抑制野生型和V599E突变型BRAF活性。

熔点: 202-204℃
沸点: 523.3℃ at 760 mmHg
外观: 白色至灰白色固体
溶解性: Soluble  in  DMSO  (~20  mg/ml),  Hot  Methanol,  DMF  (~20  mg/ml),  1:2  solution  of  DMSO:PBS(PH  7.2  )  (~0.3  mg/ml),  100%  ethanol,  and  et
储存条件: -20℃
用途: An inhibitor of tyrosine protein kinases that targets the Raf/Mek/Erk pathway
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献(17篇)

12. [IF=5.2] Pengfei Ren et al."Astaxanthin Augmented the Anti-Hepatocellular Carcinoma Efficacy of Sorafenib Through the Inhibition of the JAK2/STAT3 Signaling Pathway and Mitigation of Hypoxia within the Tumor Microenvironment."MOLECULAR NUTRITION & FOOD RESEARCH.202 11. [IF=6.1] Pengfei Ren et al."Astaxanthin slows down skeletal muscle atrophy in H22 tumor-bearing mice during sorafenib treatment by modulating the gut microbiota."Food & Function.2023 Dec;: 10. [IF=14] Tian-Jiao Zhou et al."Glutathione depletion and dihydroorotate dehydrogenase inhibition actuated ferroptosis-augment to surmount triple-negative breast cancer."BIOMATERIALS.2024 Mar;305:122447 9. [IF=6.1] Pengfei Ren et al."Dietary supplementation with astaxanthin enhances anti-tumor immune response and aids the enhancement of molecularly targeted therapy for hepatocellular carcinoma."Food & Function.2023 Aug;: 8. [IF=14] Tian-Jiao Zhou et al."Tumor microenvironment-initiated lipid redox cycling for efficient triple-negative breast cancer therapy."BIOMATERIALS.2023 Sep;300:122205 7. [IF=6.575] Pengfei Ren et al."Astaxanthin supplementation assists sorafenib in slowing skeletal muscle atrophy in H22 tumsor-bearing mice via reversing abnormal glucose metabolism."MOLECULAR NUTRITION & FOOD RESEARCH.2023 May;:2300076 6. [IF=14.026] Linlin Qu et al."Ginsenoside Rk3 is a novel PI3K/AKT-targeting therapeutics agent that regulates autophagy and apoptosis in hepatocellular carcinoma."Journal of Pharmaceutical Analysis.2023 Mar;: 5. [IF=6.388] Bei Bei Zhou et al."Vegetable-derived indole enhances the melanoma-treating efficacy of chemotherapeutics."PHYTOTHERAPY RESEARCH.2022 Jul;: 4. [IF=5.988] Wen Jiang et al."Rapid Determination of 9 Tyrosine Kinase Inhibitors for the Treatment of Hepatocellular Carcinoma in Human Plasma by QuEChERS-UPLC-MS/MS."Frontiers in Pharmacology.2022; 13: 920436 3. [IF=10.435] Li Zhe et al.Sorafenib and triptolide loaded cancer cell-platelet hybrid membrane-camouflaged liquid crystalline lipid nanoparticles for the treatment of hepatocellular carcinoma.J Nanobiotechnol. 2021 Dec;19(1):1-12 2. 刘博佳,宁青,钟荣玲,夏智,姜子瑜,宋捷,韦英杰.羽扇豆醇对人肝癌细胞HepG2和SK-HEP-1侵袭、转移的影响及机制研究[J].中国中药杂志,2020,45(24):6028-6035. 1. 黄宇哲 桂双英 储晓琴.Box-Behnken响应面法优化索拉非尼PLGA-TPGS聚合物纳米粒的处方与工艺[J].安徽中医药大学学报 2019 38(01):80-86.

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