货号	规格	价格	上海	北京	武汉	南京	购买数量
S86859-10mg	≥98%	￥4800.00 S86859-10mg ￥4800.00 2-3天	0 货期：2-3天	-	-	-

产品介绍

Narlaprevir (SCH 900518) is a selective and orally bioavailable NS3 protease inhibitor with a Ki value of 6 nM and an EC90 value of 40 nM. Narlaprevir also inhibits the HCV nonstructural protein 3 serine protease. Narlaprevir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 2.3 μM

产品描述：

靶点：

Ki: 6 nM (NS3 protease) EC90: 40 nM (NS3 protease) Ki: 7 nM (ketoamide) EC90: 40 nM (replicon RNA)

体内研究：

Pharmacokinetic AnalysisNarlaprevir (SCH 900518) exhibits middle oral bioavailability (rat 46%, dog 29%, monkey 46 %) following oral administration (rat 10 mg/kg, dog 3 mg/kg, monkey 3 mg/kg ). Narlaprevir (SCH 900518) exhibits moderate half-lives (rat 4.8 and dog 2 h) following intravenous administration (rat 4 and dog 1 mg/kg). Animal Model: rats, dogs, monkeys Dosage: Rat PO/IV 10/4 mg/kg; dog PO/IV 3/1 mg/kg; monkey PO 3 mg/kg Administration: Intravenous (i.v.) or oral gavage Result: T1/2s of 4.8 and 2 h for rats and dogs, respectively.

参考文献：

1. Ashok Arasappan, et al. Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor. ACS Med Chem Lett. 2010 Feb 15;1(2):64-9. 2. X Tong, et al. Preclinical characterization of the antiviral activity of SCH 900518 (narlaprevir), a novel mechanism-based inhibitor of hepatitis C virus NS3 protease. Antimicrob Agents Chemother. 2010 Jun;54(6):2365-70. 3. Qi Sun, et al. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther. 2021 May 29;6(1):212.

溶解性：

Soluble in DMSO

保存条件：

-20℃

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	1.413 ml	7.063 ml	14.125 ml
5 mM	0.283 ml	1.413 ml	2.825 ml
10 mM	0.141 ml	0.706 ml	1.413 ml
50 mM	0.028 ml	0.141 ml	0.283 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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