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STATIL

    
98.7%

STATIL

源叶(MedMol)
S87775 一键复制产品信息
72702-95-5
C17H12BrFN2O3
391.19
波来瑞斯
货号 规格 价格 上海 北京 武汉 南京 购买数量
S87775-2mg
98.7% ¥120.00 4 - - -
S87775-5mg
98.7% ¥200.00 6 - - -
S87775-10mg
98.7% ¥280.00 6 - - -
S87775-25mg
98.7% ¥480.00 6 - - -
S87775-50mg
≥98% ¥680.00 货期:2-3天 - - -
S87775-100mg
≥98% ¥1275.00 货期:2-3天 - - -
产品介绍 参考文献 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

Ponalrestat (ICI 128436) is an orally active, selective and noncompetitive aldose reductase (AKR1B1; ALR) inhibitor. Ponalrestat selectively inhibits ALR2 (Ki=7.7 nM) over ALR1 (Ki=60 μM). Ponalrestat inhibits the conversion of glucose to sorbitol

产品描述: Ponalrestat (ICI 128436) is an orally active, selective and noncompetitive aldose reductase (AKR1B1; ALR) inhibitor. Ponalrestat selectively inhibits ALR2 (Ki=7.7 nM) over ALR1 (Ki=60 μM). Ponalrestat inhibits the conversion of glucose to sorbitol
靶点: Ki: 7.7 nM (ALR2) and 60 μM (ALR1);Reductase
体内研究: Ponalrestat (ICI 128436; 10, 50 mg/kg; orally; daily; 8 weeks) reduces sorbitol accumulation indicating efficacy of aldose reductase inhibition. Animal Model: Adult female Sprague-Dawley rats Dosage: 10, 50 mg/kg Administration: Orally; daily; 8 weeks Result: Reduced sorbitol accumulation.
参考文献: 1. Ward WH, et al. Ponalrestat: a potent and specific inhibitor of aldose reductase. Biochem Pharmacol. 1990 Jan 15;39(2):337-46. 2. Bresson E, et al. The human aldose reductase AKR1B1 qualifies as the primary prostaglandin F synthase in the endometrium. J Clin Endocrinol Metab. 2011 Jan;96(1):210-9. 3. Calcutt NA, et al. Prevention of sensory disorders in diabetic Sprague-Dawley rats by aldose reductase inhibition or treatment with ciliary neurotrophic factor. Diabetologia. 2004 Apr;47(4):718-24.
溶解性: Soluble  in  DMSO
保存条件: RT
配置溶液浓度参考:
1mg 5mg 10mg
1 mM 2.556 ml 12.782 ml 25.563 ml
5 mM 0.511 ml 2.556 ml 5.113 ml
10 mM 0.256 ml 1.278 ml 2.556 ml
50 mM 0.051 ml 0.256 ml 0.511 ml
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献

质检证书(COA)

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摩尔浓度计算器

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