货号	规格	价格	上海	北京	武汉	南京
S88584-5mg	98.9%	￥476.00 S88584-5mg ￥476.00 现货	6 6	-	-	-
S88584-10mg	98.9%	￥680.00 S88584-10mg ￥680.00 现货	7 7	-	-	-
S88584-25mg	98.9%	￥1360.00 S88584-25mg ￥1360.00 现货	6 6	-	-	-
S88584-100mg	≥98%	￥4080.00 S88584-100mg ￥4080.00 2-3天	0 货期：2-3天	-	-	-

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产品介绍

HS-1371 is a potent and ATP-competitive receptor-interacting protein kinase 3 (RIP3) inhibitor with an IC50 of 20.8 nM

产品描述：

HS-1371 is a potent and ATP-competitive receptor-interacting protein kinase 3 (RIP3) inhibitor with an IC50 of 20.8 nM

靶点：

IC50:20.8 nM (RIP3);RIPkinase

体外研究：

HS-1371 directly binds to RIP3 in an ATP-competitive and time-independent manner. HS-1371 has an inhibitory effect on RIP3 kinase activity in various cell lines. HS-1371 (0.1, 1, 5, 10, 20 μM, 9 h) can block RIP3 S227 phosphorylation. HS-1371 (0.1, 1, 5, 10 μM, 24 h) rescues cells from RIP3-dependent necroptotic cell death but not apoptotic cell death. Western Blot Analysis Cell Line: HT-29 cells Concentration: 0.1, 1, 5, 10, 20 μM Incubation Time: 9 hours Result: Showed an inhibitory effect on S227 auto-phosphorylation of RIP3

参考文献：

1. Park HH, et al. HS-1371, a novel kinase inhibitor of RIP3-mediated necroptosis. Exp Mol Med. 2018 Sep 20;50(9):125

溶解性：

Soluble in DMSO

保存条件：

-20°C

配置溶液浓度参考：

	1mg	5mg	10mg
1 mM	2.601 ml	13.005 ml	26.01 ml
5 mM	0.52 ml	2.601 ml	5.202 ml
10 mM	0.26 ml	1.3 ml	2.601 ml
50 mM	0.052 ml	0.26 ml	0.52 ml

注意：

部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。

参考文献

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摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子摩尔量 (g/mol)

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浓度

体积

分子摩尔量

计算重置

CS-2831

HS1371