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黄芪甲苷

    
分析标准品,含量97.1%可溯源

Astragaloside IV

源叶
A10042 一键复制产品信息
84687-43-4
C41H68O14
784.97
MFCD16036240
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
A10042-20mg
分析标准品,含量97.1%可溯源

¥240.00

>10 3 2 - -

产品介绍

Astragaloside IV 是从黄芪中分离得到的一种皂苷,抑制ERK1/2和JNK激活,在乳腺癌细胞 MDA-MB-231 中,下调(MMP)-2和(MMP)-9的信号通路。

SMILES: O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1O[C@@H]2[C@@]3([H])C(C)(C)[C@@H](O[C@H]4[C@@H]([C@H]([C@@H](CO4)O)O)O)CC[C@]3(C5)[C@]65CC[C@]7(C)[C@]([C@](C)(O8)CC[C@H]8C(C)(O)C)([H])[C@@H](O)C[C@](C)7[C@]6([H])C2
熔点: 295-296°C
沸点: 895.7 °C at 760 mmHg
比旋光度:  +24.4°(c=0.23,甲醇)
外观: 无色针晶
溶解性: DMSO  :  100mg/ml
储存条件: 2-8℃
密度: 1.39
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献(28篇)

23. [IF=8.1] Li Xiaowen et al."Astragaloside IV protects against high altitude hypoxia-induced cardiac injury through the CaSR-NF-kB and EGFR-PI3K-AKT-MDM2 pathways."APOPTOSIS.2025 Oct;:1-21 22. [IF=3.4] Tianwang Wang et al."Herb-drug interaction of Astragali Radix based on in vitro incubation and pharmacokinetic assessment."BMC Complementary Medicine and Therapies.2025 Sep;25:339 21. [IF=4] Ying Huang et al."Astragaloside Ⅳ delayed the epithelial–mesenchymal transition in peritoneal fibrosis by inhibiting the activation of EGFR and PI3K-AKT pathways."Journal of Integrative Medicine-JIM.2025 Sep;: 20. [IF=4] Lidan Wu et al."Full-spectrum HPLC fingerprint with binary evaluation system and chemometrics for herbal medicine quality-efficacy control."JOURNAL OF CHROMATOGRAPHY A.2025 Oct;1761:466399 19. [IF=5.6] Long Chen et al."Engineered reconstructed extracellular vesicles coloaded with Astragaloside IV/Paeoniflorin improve cerebral ischemia/reperfusion injury by inhibiting the inflammatory response."COLLOIDS AND SURFACES B-BIOINTERFACES.2025 Nov;:115267 18. [IF=2.9] Zhao Xingyang et al."Astragaloside IV represses hepatocellular carcinoma progression by modulating HMGB1-ferroptosis axis."Discover Oncology.2025 Dec;16(1):1-11 17. [IF=2.9] Zhao Xingyang et al."Astragaloside IV represses hepatocellular carcinoma progression by modulating HMGB1-ferroptosis axis."Discover Oncology.2025 Dec;16(1):1-11 16. [IF=5.4] Yuxia Wang et al."Improvement Effect of Shengxian Decoction on Cardiac Toxicity Induced by Arsenic Trioxide in Rats."JOURNAL OF ETHNOPHARMACOLOGY.2025 Jun;:120163 15. [IF=2.5] Huaqian Mei et al."Melanin Regulation and Autophagy Modulation by Rosa centifolia L. Extract and Its Key Compounds (Astragalin and Ellagic Acid)."CHEMISTRY & BIODIVERSITY.2025 Jul;:e03168 14. [IF=4.9] Hui Xia et al."Steric hindrance scanning for activity enhancement of β-glucosidase BgMd and its application in glucoside transformation."Molecular Catalysis.2025 Sep;584:115260 13. [IF=4.6] Jili Dai et al."AS-IV Attenuates Oxidative Stress-Induced Apoptosis in Zebrafish via Modulation of the AKT/NRF2/HO-1/Caspase-3 Signaling Axis."MOLECULES.2025 May;30(11):2355 12. [IF=4.9] Xiu Wenhao et al."Inhibition of EREG/ErbB/ERK by Astragaloside IV reversed taxol-resistance of non-small cell lung cancer through attenuation of stemness via TGFβ and Hedgehog signal pathway."CELLULAR ONCOLOGY.2024 Oct;:1-15 11. [IF=3.4] Zhibo Hu et al."Astragaloside IV attenuates podocyte apoptosis via regulating TXNIP/NLRP3/GSDMD signaling pathway in diabetic nephropathy."Diabetology & Metabolic Syndrome.2024 Dec;16:296 10. [IF=8.7] Liangyin Wei et al."Oxymatrine and astragaloside IV co-loaded liposomes: Scale-up purposes and their enhancement of anti-PD-1 efficacy against breast cancer."Materials Today Bio.2025 Mar;:101634 9. [IF=4.9] Rong Gao et al."Th1/Th2 Immune Imbalance in the Spleen of Mice Induced by Hypobaric Hypoxia Stimulation and Therapeutic Intervention of Astragaloside IV."INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.2025 Jan;26(6):2584 8. [IF=4.4] Wenshuang Wang et al."Kunxinning granules alleviate perimenopausal syndrome by supplementing estrogen deficiency."Frontiers in Pharmacology.2025 Mar;16: 7. [IF=3.8] Zicong Wu et al."Astragaloside IV Treats Parkinson’s Disease by Regulating the Proliferation and Differentiation of NSCs through the SHH–Nurr1 Pathway."Stem Cells International.2024 Sep;2024(1):2792909 6. [IF=2.8] Zhu Yuanying et al."New insight into the molecular mechanism of TCM Bufei Huoxue formula for chronic obstructive pulmonary disease based on network pharmacology and experimental verification."JOURNAL OF PHARMACY AND PHARMACOLOGY.2024 Aug;: 5. [IF=3.8] Li Wei et al."Quantitative comparison of bile acid glucuronides sub-metabolome between intrahepatic cholestasis and healthy pregnant women."ANALYTICAL AND BIOANALYTICAL CHEMISTRY.2024 Jul;:1-13 4. [IF=6] Jiaheng Shan et al."β-Cyclocitral from Lavandula angustifolia Mill. Exerts Anti-Aging Effects on Yeasts and Mammalian Cells via Telomere Protection, Antioxidative Stress, and Autophagy Activation."Antioxidants.2024 Jun;13(6):715 3. [IF=10.2] Guo Hong et al."Homologous-magnetic dual-targeted metal-organic framework to improve the Anti-hepatocellular carcinoma efficacy of PD-1 inhibitor."JOURNAL OF NANOBIOTECHNOLOGY".2024 Dec;22(1):1-20 2. [IF=3.1] Yang Tao et al."Astragaloside IV modulates gut macrophages M1/M2 polarization by reshaping gut microbiota and SCFA in sepsis."SHOCK.2023 Nov;:10.1097/SHK.0000000000002262 1. [IF=5.2] Yang Ma et al."Astragaloside IV Attenuates Programmed Death-Ligand 1-Mediated Immunosuppression during Liver Cancer Development via the miR-135b-5p/CNDP1 Axis."Cancers.2023 Jan;15(20):5048

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