汉黄芩素

98. [IF=6.1] Feifan Zhou, et al. "Covalent Organic Framework Monolith Derived from Thiol–Epoxy Click Chemistry for Evaluating the Blood–Brain Barrier Permeability of Three Flavonoids from Alpiniae oxyphylla fructus"TALANTA, 2026 Apr;:129834 97. [IF=8.3] Guanhua Zhang, et al. "Spatiotemporal dynamics of morphology-metabolism interplay in Scutellaria baicalensis hollow root morphogenesis via spatially resolved metabolomics"PHYTOMEDICINE, 2026 Apr;:158229 96. [IF=8.3] Zhuolin Guo, et al. "Deciphering the core antiviral mechanism of Yinqiao Powder: Inhibition of dengue virus adsorption mediated by wogonin via host receptor HSP90AA1 blockade"PHYTOMEDICINE, 2026 Apr;:158184 95. [IF=1.7] Jingju Fu, et al. "Fingerprint Analysis and Quality Marker Identification of Sanhuang Xiexin Decoction Based on Integrated Phytochemical and Chemometric Approaches"BIOMEDICAL CHROMATOGRAPHY, 2026 May;40(6):e70477 94. [IF=3.1] Ji Wanli et al."Banxia Xiexin Decoction modulates short-chain fatty acid metabolism and mitigates ulcerative colitis by reshaping the intestinal microbiota."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.2026 Apr;271:117332 93. [IF=4.6] Guiling Peng et al."Construction of a multidimensional quality evaluation system for Scutellariae Radix: Integrated research on chemical components, biological potency, near-infrared spectroscopy technology, and intelligent algorithms."SPECTROCHIMICA ACTA
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￿￿Ɓ￿￿ñ 92. [IF=3.4] Liting Ma et al."Scutellaria baicalensis extract prevents metabolic dysfunction-associated steatotic liver disease by modulating the gut-liver axis in high-fat diet mice."PHYTOCHEMISTRY.2025 Nov;:114720 91. [IF=6.2] Xue Hu et al."Validation of Insect Dopa Decarboxylase as a Potential Insecticide Target and Discovery of Selective Lead Compounds."JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY.2025;XXXX(XXX):XXX-XXX 90. [IF=2.3] Yuxin Jiang et al."Elucidating the Therapeutic Mechanism of Danggui Liuhuang Decoction in Hyperthyroid Kidney Disease: An Integration of Network Pharmacology and Metabolomics."International Journal of Endocrinology.2025 Sep;2025(1):5513418 89. [IF=3.1] Yifan Bing et al."Antidepressant efficacy and Q-markers determination of Dachaihu decoction: Combining pharmacology, correlation analysis, and network pharmacology approaches."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.2026 Jan;267:117169 88. [IF=5.5] Guoliang Wu et al."Therapeutic Potential of Wogonin–Aloperine Co-Amorphous for Oral Squamous Cell Carcinoma."Pharmaceutics.2025 Sep;17(9):1204 87. [IF=8.3] Shufang Li et al."Daphnetin as a novel polyphosphate kinase inhibitor to combat Salmonella infection."PHYTOMEDICINE.2025 Nov;148:157278 86. [IF=1.7] Fansheng Meng et al."Inhibitory effects of wogonin on hepatocellular carcinoma through modulation of lactate metabolism and suppression of regulatory T-cell differentiation."European Journal of Integrative Medicine.2025 Sep;78:102545 85. [IF=1.7] Fansheng Meng et al."Inhibitory effects of wogonin on hepatocellular carcinoma through modulation of lactate metabolism and suppression of regulatory T-cell differentiation."European Journal of Integrative Medicine.2025 Sep;78:102545 84. [IF=2.5] Weixian Shao et al."Study on the Specifications of Scutellariae Radix in Da-Chai-Hu-Tang Based on Efficacy in a Rat Model of Large Intestine Damp-Heat Syndrome and Chemical Composition Differences."CHEMISTRY & BIODIVERSITY.2025 Jul;:e01198 83. [IF=5.4] Ni Xu et al."Modulation of Glycolytic Metabolic Reprogramming and the TLR4/NF-κB/NLRP3 Pathway: Comparative Analysis of Anti-inflammatory Activity Between Two Dosage Forms of Pudilan Xiaoyan."JOURNAL OF ETHNOPHARMACOLOGY.2025 Jun;:120204 82. [IF=14.1] Chuanrui Ma et al."Wogonin Attenuates Atherosclerosis via KLF11-Mediated Suppression of PPARα-YAP1-Driven Glycolysis and Enhancement of ABCA1/G1-Mediated Cholesterol Efflux."Advanced Science.2025 May;:2500610 81. [IF=2.7] Dan-ni Chen et al."Promotion of a quality standard for Scutellariae radix based on the anti-inflammatory efficacy-oriented quality marker of the effect-constituent index."Analytical Methods.2024 Nov;: 80. [IF=3.8] Song Yang et al."Wogonin suppresses proliferation, invasion and migration in gastric cancer cells via targeting the JAK-STAT3 pathway."Scientific Reports.2024 Dec;14(1):1-15 79. [IF=4.8] Xian-Heng Zhang et al."Chinese herbal medicines and its active ingredient wogonin can improve immune inflammation in psoriatic arthritis."INTERNATIONAL IMMUNOPHARMACOLOGY.2025 Feb;147:113984 78. [IF=3.1] Yang Hui et al."Wogonin attenuates inflammation and oxidative stress in acute lung injury via regulating PPARα, AKT, and NRF2."NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY.2025 Feb;:1-12 77. [IF=1.2] Meili Yang et al."Exploring the potential mechanism of Andrographis paniculata compounds against neurodegenerative diseases based on network pharmacology and molecular docking."CHINESE JOURNAL OF ANALYTICAL CHEMISTRY.2025 Feb;:100514 76. [IF=6.7] Jingyan Zhang et al."Scutellaria baicalensis Extracts Restrict Intestinal Epithelial Cell Ferroptosis by Regulating Lipid Peroxidation and GPX4/ACSL4 in Colitis."PHYTOMEDICINE.2025 Mar;:156708 75. [IF=5.6] Hao Guo et al."Research on the synergistic optimization of Scutellaria baicalensis yield, quality and soil environment by key microorganisms, driven by the combined approach of reducing chemical fertilizer usage while incorporating organic fertilizer."IND 74. [IF=5.1] Jing-Qun Liu et al."Apigenin ameliorates lupus nephritis by inhibiting SAT3 signaling in CD8+T cells."Food & Function.2024 Sep;: 73. [IF=4.2] Xinyue Wang et al."Mechanistic investigation of wogonin in delaying the progression of endothelial mesenchymal transition by targeting the TGF-β1 pathway in pulmonary hypertension."EUROPEAN JOURNAL OF PHARMACOLOGY.2024 Sep;978:176786 72. [IF=4.3] Hujun Du et al."Exploring the Underlying Mechanisms of Qingxing Granules Treating H1N1 Influenza Based on Network Pharmacology and Experimental Validation."Pharmaceuticals.2024 Jun;17(6):731 71. [IF=5.7] Yujing Liu et al."Wogonin Inhibits Colorectal Cancer Proliferation and Epithelial Mesenchymal Transformation by Suppressing Phosphorylation in the AKT Pathway."AMERICAN JOURNAL OF CHINESE MEDICINE.10.1142/S0192415X24500460 70. [IF=7.9] Yanqin Luo et al."Scutellaria baicalensis water decoction ameliorates lower respiratory tract infection by modulating respiratory microbiota."PHYTOMEDICINE".2024 May;:155706 69. [IF=1.6] Zhang Jie et al."Exploration of the effect and mechanism of Scutellaria barbata D. Don in the treatment of ovarian cancer based on network pharmacology and in vitro experimental verification."MEDICINE.2023 Dec;102(51):e36656 68. [IF=1.8] Yue Qian et al."Si Miao San relieves hyperuricemia by regulating intestinal flora."BIOMEDICAL CHROMATOGRAPHY.2023 Dec;:e5807 67. [IF=5.4] Botong Li et al."Protective effect of San Huang Pill and its bioactive compounds against ulcerative colitis in Drosophila via modulation of JAK/STAT, apoptosis, Toll, and Nrf2/Keap1 pathways."JOURNAL OF ETHNOPHARMACOLOGY.2024 Mar;322:117578 66. [IF=5.4] Liangxin Zhao et al."UPLC-Q-Exactive/MS based analysis explore the correlation between components variations and anti-influenza virus effect of four quantified extracts of Chaihu Guizhi decoction."JOURNAL OF ETHNOPHARMACOLOGY.2023 Oct;:117318 65. [IF=1.8] Ying Yang et al."Anti-osteoporosis bioactivity evaluation in zebrafish model of raw and salt-processed Achyranthes bidentata followed by liquid chromatography–mass spectrometry analysis and correlation analysis."BIOMEDICAL CHROMATOGRAPHY.10.1002/bmc.5742 64. [IF=7] Caijun Ren et al."Antioxidant Polyphenols from Lespedeza bicolor Turcz. Honey: Anti-Inflammatory Effects on Lipopolysaccharide-Treated RAW 264.7 Macrophages."Antioxidants.10.3390/antiox12101809 63. [IF=4.3] Bao-Fei Yan et al."Huangqin decoction alleviates lipid metabolism disorders and insulin resistance in nonalcoholic fatty liver disease by triggering Sirt1/NF-κB pathway."WORLD JOURNAL OF GASTROENTEROLOGY.2023 Aug 21; 29(31): 4744–4762 62. [IF=5.2] Guo Huanyu et al."The combined effect of a novel formula of herbal extracts on bacterial infection and immune response in Micropterus salmoides."Frontiers in Microbiology.2023 Jun;14: 61. [IF=5.4] Miaomiao Liu et al."Qingjin Huatan decoction protects mice against influenza a virus pneumonia via the chemokine signaling pathways."JOURNAL OF ETHNOPHARMACOLOGY.2023 Dec;317:116745 60. [IF=1.555] Huang Zhen et al."Screening Antibacterial Constituents of Scutellaria Radix Based on Spectrum–Effect Relationships Between HPLC Fingerprints and the Inhibition of Oral Bacteria."JOURNAL OF CHROMATOGRAPHIC SCIENCE.2023 Mar;: 59. [IF=3.246] Yue Qian et al."A Network Pharmacology Method Combined with Molecular Docking Verification to Explore the Therapeutic Mechanisms Underlying Simiao Pill Herbal Medicine against Hyperuricemia."Biomed Research International.2023;2023:2507683 58. [IF=2.586] Jiaxin Yin et al."Comprehensive multicomponent characterization and quality assessment of Shuang-Huang-Lian powder injection using ultra-high-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry and ultra-high-performance liquid c 57. [IF=4.831] Jing Sun et al."Fourier transform infrared spectroscopic markers of the scorching degree of Scutellariae Radix related to the variation patterns of flavonoids and carbohydrates."SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY.2023 Apr;2 56. [IF=7.169] Dong Ya-ping et al."Skullcapflavone II, a novel NQO1 inhibitor, alleviates aristolochic acid I-induced liver and kidney injury in mice."ACTA PHARMACOLOGICA SINICA.2023 Jan;:1-13 55. [IF=3.318] Hui Luo et al."Efficacy identification and active compounds screening of topically administration of Scutellaria Radix in oral ulcer."JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES.2022 Dec;:123571 54. [IF=5.195] Bao-Fei Yan et al."Huangqin decoction mitigates hepatic inflammation in high-fat diet-challenged rats by inhibiting TLR4/NF-κB/NLRP3 pathway."JOURNAL OF ETHNOPHARMACOLOGY.2023 Mar;303:115999 53. [IF=7.291] Liu Xiaojuan et al."Genome-wide analysis of cytochrome P450 genes in Citrus clementina and characterization of a CYP gene encoding flavonoid 3'-hydroxylase."Horticulture Research.2022 Dec;: 52. [IF=5.195] Xiaojing Wang et al."Gegen Qinlian decoction activates AhR/IL-22 to repair intestinal barrier by modulating gut microbiota-related tryptophan metabolism in ulcerative colitis mice."JOURNAL OF ETHNOPHARMACOLOGY.2022 Nov;:115919 51. [IF=5.195] Weicong Chen et al."Biejiajian pill inhibits progression of hepatocellular carcinoma by downregulating PDGFRβ signaling in cancer-associated fibroblasts."JOURNAL OF ETHNOPHARMACOLOGY.2022 Oct;:115825 50. [IF=5.168] Pan Wang et al."Discovery and characterization of novel ATP citrate lyase inhibitors from natural products by a luminescence-based assay."CHEMICO-BIOLOGICAL INTERACTIONS.2022 Nov;367:110199 49. [IF=5.195] Zhen Huang et al."Efficacy confirmation of Scutellaria baicalensis Georgi in the treatment of periodontitis via topical administration and active ingredients screening."JOURNAL OF ETHNOPHARMACOLOGY.2023 Jan;300:115699 48. [IF=5.195] Xin Deng et al."A novel strategy for active compound efficacy status identification in multi-tropism Chinese herbal medicine (Scutellaria baicalensis Georgi) based on multi-indexes spectrum-effect gray correlation analysis."JOURNAL OF ETHNOPHARMACOLOGY.20 47. [IF=5.895] Junxiu Wang et al."Betulin, Synthesized by PpCYP716A1, Is a Key Endogenous Defensive Metabolite of Peach against Aphids."JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY.2022;70(40):12865–12877 46. [IF=6.208] Pan Wang et al."Discovery of Flavonoids as Novel Inhibitors of ATP Citrate Lyase: Structure–Activity Relationship and Inhibition Profiles."INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.2022 Jan;23(18):10747 45. [IF=6.212] Fei Huang et al."Discovery of conversion driven by β-glucuronidase from flavone glycoside to aglycone and application in identifying the raw Scutellariae Radix."Arabian Journal of Chemistry.2022 Aug;:104216 44. [IF=3.614] Huanyu Guan et al."Deciphering the chemical constituents of Shengjiang Xiexin decoction by ultra-high-performance liquid chromatography-quadrupole/orbitrap high-resolution mass spectrometry and the impact of 20 characteristic components on multidrug resis 43. [IF=5.195] Mengmeng Song et al."Homeostatic regulation of the aryl hydrocarbon receptor-cytochrome P450 1a axis by Scutellaria baicalensis-Coptis chinensis herb pair and its main constituents."JOURNAL OF ETHNOPHARMACOLOGY.2022 Jul;:115545 42. [IF=8.025] Ying Wang et al."Inhibitory activities of flavonoids from Scutellaria baicalensis Georgi on amyloid aggregation related to type 2 diabetes and the possible structural requirements for polyphenol in inhibiting the nucleation phase of hIAPP aggregation."INT 41. [IF=7.514] Jie Meng et al."Conduction of a chemical structure-guided metabolic phenotype analysis method targeting phenylpropane pathway via LC-MS: Ginkgo biloba and soybean as examples."FOOD CHEMISTRY. 2022 Oct;390:133155 40. [IF=3.935] Yizhu Wang et al."Effects of Scutellaria baicalensis Georgi. on Intestinal Flora in Rats with Spleen Deficiency and Damp-heat."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2022 May;:114831 39. [IF=5.268] Bingyan Yang et al."Improved stability and pharmacokinetics of wogonin through loading into PASylated ferritin."COLLOIDS AND SURFACES B-BIOINTERFACES. 2022 Aug;216:112515 38. [IF=5.923] Shiwei Wang et al.Inhibition of Virulence Factors and Biofilm Formation by Wogonin Attenuates Pathogenicity of Pseudomonas aeruginosa PAO1 via Targeting pqs Quorum-Sensing System.Int J Mol Sci. 2021 Jan;22(23):12699 37. [IF=2.447] Fang-Mei Zhou et al."Protective effects of flavonoids from the leaves of Carya cathayensis Sarg. against H₂O₂‑induced oxidative damage and apoptosis in vitro."Exp Ther Med. 2021 Dec;22(6):1-11 36. [IF=2.629] Wang Hui-Nan et al."Comparison of Pharmacokinetics and Tissue Distribution Characteristics of Three Diterpenoid Esters in Crude and Prepared Semen Euphorbiae."Evid-Based Compl Alt. 2021;2021:7402120 35. [IF=2.877] Wanli Ji et al."Identifying the active compounds and mechanism of action of Banxia Xiexin decoction for treating ethanol-induced chronic gastritis using network pharmacology combined with UPLC–LTQ–Orbitrap MS."Comput Biol Chem. 2021 Aug;93:107535 34. [IF=3.361] Mengmeng Yuan et al."The interaction of dietary flavonoids with xanthine oxidase in vitro: molecular property-binding affinity relationship aspects."Rsc Adv. 2019 Apr;9(19):10781-10788 33. [IF=3.935] Chenglong Sun et al."A spatially-resolved approach to visualize the distribution and biosynthesis of flavones in Scutellaria baicalensis Georgi."J Pharmaceut Biomed. 2020 Feb;179:113014 32. [IF=4.759] Yi Zhang et al."Screening of inhibitors against histone demethylation jumonji domain-containing protein 3 by capillary electrophoresis."J Chromatogr A. 2020 Feb;1613:460625 31. [IF=4.759] Yueping Jiang et al."Application of multifold characteristic ion filtering combined with statistical analysis for comprehensive profiling of chemical constituents in anti-renal interstitial fibrosis I decoction by ultra-high performance liquid chromatogra 30. [IF=5.11] Xiaonan Liu et al."De Novo Biosynthesis of Multiple Pinocembrin Derivatives in Saccharomyces cerevisiae."Acs Synth Biol. 2020;9(11):3042–3051 29. [IF=5.279] Wenqin Li et al."Discovery of Natural Products as Multitarget Inhibitors of Insect Chitinolytic Enzymes through High-Throughput Screening."J Agr Food Chem. 2021;69(37):10830–10837 28. [IF=5.81] Cui Lihua et al."Chaihu Guizhi Ganjiang Decoction Ameliorates Pancreatic Fibrosis via JNK/mTOR Signaling Pathway."Front Pharmacol. 2021 Jun;0:1369 27. [IF=3.205] Zhuangzhuang Li et al."Simultaneous quantification of fifteen compounds in rat plasma by LC-MS/MS and its application to a pharmacokinetic study of Chaihu-Guizhi decoction."J Chromatogr B. 2019 Jan;1105:15 26. [IF=3.361] Huanyu Guan et al."Comparative intestinal bacteria-associated pharmacokinetics of 16 components of Shengjiang Xiexin decoction between normal rats and rats with irinotecan hydrochloride (CPT-11)-induced gastrointestinal toxicity in vitro using salting-out 25. [IF=3.935] Yanqiu Gu et al."Comparative two-dimensional HepG2 and L02/ cell membrane chromatography/ C18/ time-of-flight mass spectrometry for screening selective anti-hepatoma components from Scutellariae Radix."J Pharmaceut Biomed. 2019 Feb;164:550 24. [IF=3.935] Ka-Yan Kwok et al."Quality evaluation of commercial Huang-Lian-Jie-Du-Tang based on simultaneous determination of fourteen major chemical constituents using high performance liquid chromatography."J Pharmaceut Biomed. 2013 Nov;85:239 23. Xu, Jun. "Improved approaches and strategies for analyzing decoctions of medicinal herbs." (2016). 22. Yanqiu, et al. "Comparative two-dimensional HepG2 and L02/ cell membrane chromatography/ C18/ time-of-flight mass spectrometry for screening selective anti-hepatoma components from Scutellariae Radix. " Journal of pharmaceutical and biomedical analysis 164 21. Sun, Chenglong, et al. "A spatially-resolved approach to visualize the distribution and biosynthesis of flavones in Scutellaria baicalensis Georgi." Journal of pharmaceutical and biomedical analysis 179 (2020): 113014.https://doi.org/10.1016/j.jpba.2019.11 20. Cheng, Yan, et al. "Controlled Extraction of Flavonoids From Radix Scutellariae by Subcritical Water." CLEAN–Soil, Air, Water 44.3 (2016): 299-303.https://doi.org/10.1002/clen.201300193 19. 莉莉,陈勇,张蒙伟,鄢红霞,高守红,陈万生.UHPLC-MS/MS法测定新冠肺炎经验方寒湿郁肺汤中11种主成分的含量[J].药学实践杂志,2021,39(02):148-151+156. 18. 张慧, 李思雨, 冯宏玲,等. 基于效应成分指数的双黄连制剂质量控制研究[J]. 药学学报, 2019, 054(012):2149-2154. 17. 任永申, 邓鑫, 雷蕾,等. 基于抑菌效应成分指纹谱的黄芩质量评价研究[J]. 药学学报, 2019, 054(012):2155-2161. 16. 袁杰, 李锬, 周利,等. 基于超高效液相色谱法和色差仪法的黄芩药材质量评价[J]. 世界中医药, 2019. 15. 李云静, 张建逵, 赵玥,等. 黄芩药材颜色及其有效成分的相关性[J]. 中国医药工业杂志, 2017(7). 14. 商利娜, 王亚静, 赵鑫,等. 基于谱-效关系探究黄芩抑制白色念珠菌的质量标志物[J]. 中成药, 2020, 042(005):1357-1361. 13. 柴冲冲,曹妍,毛民,王靖越,刘娜,李欣欣,张凯,陈东玲,魏龙吟,尹怡慧,李飞.基于电子舌技术评价黄芩酒炙前后滋味变化及其在黄芩饮片鉴别中的应用研究[J].中国中药杂志,2020,45(11):2552-2559. 12. 柴冲冲 毛民 袁金凤 等. 不同方法软化切制后的黄芩饮片颜色与5种黄酮类成分含量的相关性研究[J]. 中国中药杂志 2019. 11. 王子凌云 梁琨 李国文. HPLC法测定芩杏清热止咳颗粒中8种成分[J]. 中成药 2019 041(005):995-999. 10. 程燕, 曲绍风, 李福伟,等. 黄芩中4种黄酮类化合物的亚临界水提取研究[J]. 山东科学, 2013(03):11-14. 9. 刘媛媛, 刘陶, 吴玉梅,等. 基于雌激素受体调节Nrf2-ARE通路的黄芩中抗氧化成分的筛选[J]. 中国药理学通报, 2019, 035(006):822-827. 8. 李淑娇, 王宇卿. 基于HPLC-Q-TOF/MS法的黄芩血清药物化学分析[J]. 中成药, 2019, 41(03):117-122. 7. 王东超 魏颖 高佳琪 孙文 秦灵灵 兰卫 石浩霞 李博 徐暾海 刘铜华.HPLC同时测定糖痹康颗粒中黄芩苷、汉黄芩苷、黄芩素、汉黄芩素的含量[J].吉林中医药 2017 37(05):513-517. 6. 张婕,梁程程,杨爱仲,齐聪.增免抑瘤方及有效组分对卵巢癌干细胞裸鼠移植瘤Notch/Jagged1信号通路的影响[J].中国实验方剂学杂志,2020,26(15):46-53. 5. 李云静 张建逵 王冰 等. 不同产地黄芩药材中黄芩苷等5种黄酮类成分含量的比较[J]. 时珍国医国药 2016 027(012):2985-2988. 4. 许琳, 王营, 陈复兴,等. 汉黄芩素对人NK细胞杀伤胃癌MKN45细胞的影响及其机制研究[J]. 免疫学杂志, 2014, 030(009):804-808. 3. 刘佳卓 王若琪 柳文媛. 反相高效液相色谱法测定千层纸素的含量和有关物质[J]. 中南药学 2019 017(001):93-98. 2. 段飞鹏 王英姿 李韶菁 等. 千金子甾醇在Caco-2细胞单层模型中的吸收研究[J]. 中草药 2014 45(021):3136-3140. 1. 何悦 王四旺 肖会敏. HPLC法同时测定复方金银花颗粒中10种成分的含量[J]. 药学实践杂志 2019 037(002):177-182.