人参皂苷CK

71. [IF=2.5] Qiaoxiang Wu et al."A new UDP-glycosyltransferase for rare ginsenoside biosynthesis from Gynostemma pentaphyllum (Thunb.)."CARBOHYDRATE RESEARCH.2025 Dec;558:109703 70. [IF=7.3] Xueni Yan et al."Green Biomanufacturing of High-Value Ginsenoside F2 Using β-Glucosidase Smbgl3 in a Tailored Deep Eutectic Solvent-Containing Buffer System."ACS Sustainable Chemistry & Engineering.2025;13(43):18689–18702 69. [IF=8.3] Wen Li et al."Ginsenoside compound K ameliorates depressive-like behaviors by targeting kynurenine 3-monooxygenase."PHYTOMEDICINE.2025 Sep;:157335 68. [IF=4.9] Xinmiao Yu et al."Comprehensive Quality Evaluation and In Vivo Process Study of Ginsenoside CK Inclusion Complex through obese insulin resistance."JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY.2025 Aug;:107371 67. [IF=4.9] Xinmiao Yu et al."Comprehensive Quality Evaluation and In Vivo Process Study of Ginsenoside CK Inclusion Complex through obese insulin resistance."JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY.2025 Aug;:107371 66. [IF=8.3] Xiayun Pang et al."Rhizoma Panacis Majoris ameliorates rheumatoid arthritis by restoring apoptosis and autophagy dysregulation through reducing HMGB1 expression."PHYTOMEDICINE.2025 Jun;:156943 65. [IF=8.5] Chengcheng Li et al."Cellulase hyperproduction Trichoderma reesei mutant strain BB8 for the bioextraction and bioconversion of ginsenoside from Panax notoginseng."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2025 Jun;:144984 64. [IF=3.8] Qin Wei et al."Target Identification of Ginsenosides Against Cognitive Impairment by Using Mass Spectrometry-Based Cellular Thermal Shift Assay (CETSA)."NEUROCHEMICAL RESEARCH.2025 Jun;50(3):1-17 63. [IF=3.1] Ze-xuan Chen et al."Metabolite profiling of Shenhua compound in rats and pharmacokinetics study of four bioactive compounds with liquid chromatography combined with electrospray ionization tandem mass spectrometry."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL 62. [IF=14.7] Chuanjing Cheng et al."Ginsenoside CK targets PHD2 to prevent platelet adhesion and enhance blood circulation by modifying the three-dimensional arrangement of collagen."Acta Pharmaceutica Sinica B.2024 Dec;: 61. [IF=6.2] Peng Yu et al."Ginsenosides 20R-Rg3 and Rg5 enriched black ginseng inhibits colorectal cancer tumor growth by activating the Akt/Bax/caspase-3 pathway and modulating gut microbiota in mice."Current Research in Food Science.2025 Jan;10:100978 60. [IF=3.3] Xu Yang et al."Protective effect of ginsenoside CK against MPTP-induced Parkinson’ s disease mouse model by suppressing oxidative stress and inflammation, and modulating the gut microbiota."MICROBIAL PATHOGENESIS.2025 May;202:107409 59. [IF=4.8] Cuiting Yang et al."Fermentation interactions and lipid-lowering potential of Monascus purpureus fermented Ginseng."Food Bioscience.2025 Apr;66:106260 58. [IF=6.8] Feiyan Chen et al."Identification of AIF1 as a protein target of notoginsenosides in brain tissue of mice with intracerebral hemorrhage based on hapten immunoaffinity fishing technique."Journal of Ginseng Research.2025 Apr;: 57. [IF=3.8] Chen Yue et al."Impact of ginsenoside Rb1 on gut microbiome and associated changes in pharmacokinetics in rats."Scientific Reports.2024 Sep;14(1):1-12 56. [IF=3.8] Yuan Liang et al."Ginsenoside CK ameliorates tumor growth in lung cancer mice via inhibiting EGFR."Journal of Functional Foods.2024 Oct;121:106446 55. [IF=1.3] Hong-Ping Wang et al."Screening of GLP-1r agonists from natural products using affinity ultrafiltration screening coupled with UPLC-ESI-Orbitrap-MS technology: a case study of Panax ginseng."JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH. 54. [IF=3.5] Hong Yinan et al."Biotransformation of ginsenoside compound K using β-glucosidase in deep eutectic solvents."BIOPROCESS AND BIOSYSTEMS ENGINEERING.2024 Jun;:1-11 53. [IF=3.9] Chen Jiaxin et al."Ginsenoside compound K induces ferroptosis via the FOXO pathway in liver cancer cells."BMC Complementary Medicine and Therapies".2024 Dec;24(1):1-13 52. [IF=5.2] Yanbo Hu et al."Targeted preparation of six rare ginsenosides using two β-glucosidases from Bifidobacterium adolescentis."Food Bioscience".2024 Jun;59:104192 51. [IF=2.7] Wenjie Su et al."Therapeutic effect of notoginseng saponins before and after fermentation on blood deficiency rats."Experimental and Therapeutic Medicine".2024 Apr;27(4):1-16 50. [IF=5] Xiaoyan You et al."Multifunctional Liposomes Co-Modified with Ginsenoside Compound K and Hyaluronic Acid for Tumor-Targeted Therapy."Polymers".2024 Jan;16(3):405 49. [IF=0.7] Yang Bai et al."Ginsenoside CK Induces the Mitochondrial Apoptosis in Glioma Cells Through the Activation of the p53-Bax-Caspase Pathway."Pharmacognosy Magazine.;(): 48. [IF=1.6] Dai Tingting et al."Prediction of molecular mechanism of processed ginseng in the treatment of heart failure based on network pharmacology and molecular docking technology."MEDICINE.2023 Dec;102(49):e36576 47. [IF=5.8] Ziwei Li et al."Oral liposomes encapsulating ginsenoside compound K for rheumatoid arthritis therapy."INTERNATIONAL JOURNAL OF PHARMACEUTICS.2023 Jul;:123247 46. [IF=7.2] Jinfen Chen et al."20(S)- Protopanaxadiol saponins isolated from Panax notoginseng target the binding of HMGB1 to TLR4 against inflammation in experimental ulcerative colitis."PHYTOTHERAPY RESEARCH.2023 Jul;: 45. [IF=3.2] Yuqing Xu et al."Optimization of Rare Ginsenosides and Antioxidant Activity Quality of Ginseng Jiaosu Based on Probiotic Strains and Fermentation Technology."JOURNAL OF FOOD QUALITY.2023;2023:5686929 44. [IF=5.735] Feiyan Chen et al."Discovery and validation of PURA as a transcription target of 20(S)-protopanaxadiol: Implications for the treatment of cognitive dysfunction."Journal of Ginseng Research.2023 Apr;: 43. [IF=5.223] Xiao-Li Li et al."Effect of ginsenoside CK combined with cisplatin on the proliferation and migration of human cervical cancer HeLa cells via Ras/ERK/MAPK pathway."Journal of Functional Foods.2023 Mar;102:105438 42. [IF=6.751] Xiaodi Niu et al."Antifungal activity of ginsenoside CK against Botrytis cinerea by targeting sterol 14α-demethylase cytochrome P450 (CYP51) and the application on cherry tomato preservation."POSTHARVEST BIOLOGY AND TECHNOLOGY.2023 May;199:112294 41. [IF=3.776] Yuzhu Hou et al."Anti-cancer effects of ginsenoside CK on acute myeloid leukemia in vitro and in vivo."Heliyon.2022 Dec;8:e12106 40. [IF=4.927] Qinhua Zheng et al."Protective Effect of Flavonoids from Mulberry Leaf on AAPH-Induced Oxidative Damage in Sheep Erythrocytes."MOLECULES.2022 Jan;27(21):7625 39. [IF=3.268] Jiaxin Chen et al."Ginsenoside compound K induces mitochondrial apoptosis in human hepatoma cells through Bclaf1-mediated modulation of ERK signaling."FOOD AND AGRICULTURAL IMMUNOLOGY 38. [IF=5.168] Pan Wang et al."Discovery and characterization of novel ATP citrate lyase inhibitors from natural products by a luminescence-based assay."CHEMICO-BIOLOGICAL INTERACTIONS.2022 Nov;367:110199 37. [IF=6.055] Baoyu Fu et al."Ginsenosides improve reproductive capability of aged female Drosophila through mechanism dependent on ecdysteroid receptor (ECR) and steroid signaling pathway."Frontiers in Endocrinology.2022; 13: 964069 36. [IF=2.419] Yinping Jin et al."Dynamic changes of ginsenosides in Panax quinquefolius fruit at different development stages measured by UHPLC-Orbitrap MS."Rapid Communications In Mass Spectrometry. 2022 Feb 17 35. [IF=4.432] Shuai Zhang et al."Ginsenoside Rf inhibits human tau proteotoxicity and causes specific LncRNA, miRNA and mRNA expression changes in Caenorhabditis elegans model of tauopathy."Eur J Pharmacol. 2022 May;922:174887 34. [IF=1.632] Wu Song et al."Ginsenoside compound K inhibits oxidative stress and NLRP3 inflammasome activity in mice exposed to chronic unpredictable mild stress."Biotechnol Biotec Eq. 2019;33(1):1372-1379 33. [IF=2.055] Qian Chen et al."Shenyan Kangfu tablet alleviates diabetic kidney disease through attenuating inflammation and modulating the gut microbiota."J Nat Med-Tokyo. 2021 Jan;75(1):84-98 32. [IF=2.629] Zhang Meiyu et al."In Vitro Transformation of Protopanaxadiol Saponins in Human Intestinal Flora and Its Effect on Intestinal Flora."Evid-Based Compl Alt. 2021;2021:1735803 31. [IF=3.21] Ma Zhu et al."Transformation of ginsenoside via deep eutectic solvents based on choline chloride as an enzymatic reaction medium."Bioproc Biosyst Eng. 2020 Jul;43(7):1195-1208 30. [IF=3.978] Weina Li et al."Ginsenoside CK production by commercial snailase immobilized onto carboxylated chitosan-coated magnetic nanoparticles."Biochem Eng J. 2021 Oct;174:108119 29. [IF=5.396] Hui Wang et al."Ginsenoside extract from ginseng extends lifespan and health span in Caenorhabditis elegans."Food Funct. 2021 Aug;12(15):6793-6808 28. [IF=6.023] Chenfei Li et al."Elucidation of interaction between serum albumin and ginsenoside CK along with cytotoxic study."Food Chem Toxicol. 2021 Sep;155:112403 27. [IF=9.642] Xin Han et al."Biocatalytic production of compound K in a deep eutectic solvent based on choline chloride using a substrate fed-batch strategy."Bioresource Technol. 2020 Jun;305:123039 26. [IF=3.06] Xuan Zhang et al."Compound K Induces Endoplasmic Reticulum Stress and Apoptosis in Human Liver Cancer Cells by Regulating STAT3."Molecules. 2018 Jun;23(6):1482 25. [IF=3.935] Shan-Shan Zhou et al."Synchronous characterization of carbohydrates and ginsenosides yields deeper insights into the processing chemistry of ginseng."J Pharmaceut Biomed. 2017 Oct;145:59 24. [IF=3.935] Hong Zhang et al."A multidimensional analytical approach based on time-decoupled online comprehensive two-dimensional liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry for the analysis of ginsenosides from white a 23. [IF=3.935] Hong-Mei Zhang et al."Holistic quality evaluation of commercial white and red ginseng using a UPLC-QTOF-MS/MS-based metabolomics approach."J Pharmaceut Biomed. 2012 Mar;62:258 22. [IF=4.36] Bin Ma et al."Sulfur fumigation reducing systemic exposure of ginsenosides and weakening immunomodulatory activity of ginseng."J Ethnopharmacol. 2017 Jan;195:222 21. [IF=4.952] Jiali Chen et al."Ginsenosides and amino acids in flavored ginseng chips as affected by food formulation and processing technology."Lwt Food Sci Technol. 2015 Jun;62:517 20. [IF=5.34] Shan-Shan Zhou et al."Stronger anti-obesity effect of white ginseng over red ginseng and the potential mechanisms involving chemically structural/compositional specificity to gut microbiota."Phytomedicine. 2020 Aug;74:152761 19. [IF=6.06] Jiahong Han et al."Compatibility effects of ginseng and Ligustrum lucidum Ait herb pair on hematopoietic recovery in mice with cyclophosphamide-induced myelosuppression and its material basis."J Ginseng Res. 2020 Mar;44:291 18. Joo, Kyung-Mi, et al. "Pharmacokinetic study of ginsenoside Re with pure ginsenoside Re and ginseng berry extracts in mouse using ultra performance liquid chromatography/mass spectrometric method." Journal of pharmaceutical and biomedical analysis 51.1 (20 17. Hong Zhang, Jia-Ming Jiang, Dan Zheng, Ming Yuan, Zhi-Ying Wang, Hong-Mei Zhang, Chang-Wu Zheng, Lian-Bo Xiao, Hong-Xi Xu, A multidimensional analytical approach based on time-decoupled online comprehensive two-dimensional liquid chromatography coupled wit 16. Hong Zhang, Jia-Ming Jiang, Dan Zheng, Ming Yuan, Zhi-Ying Wang, Hong-Mei Zhang, Chang-Wu Zheng, Lian-Bo Xiao, Hong-Xi Xu, A multidimensional analytical approach based on time-decoupled online comprehensive two-dimensional liquid chromatography coupled wit 15. Hong Zhang, Jia-Ming Jiang, Dan Zheng, Ming Yuan, Zhi-Ying Wang, Hong-Mei Zhang, Chang-Wu Zheng, Lian-Bo Xiao, Hong-Xi Xu, A multidimensional analytical approach based on time-decoupled online comprehensive two-dimensional liquid chromatography coupled wit 14. Han, Xin, et al. "Biocatalytic production of compound K in a deep eutectic solvent based on choline chloride using a substrate fed-batch strategy." Bioresource technology 305 (2020): 123039.https://doi.org/10.1016/j.biortech.2020.123039 13. Zhang, Xuan, et al. "Compound K induces endoplasmic reticulum stress and apoptosis in human liver cancer cells by regulating STAT3." Molecules 23.6 (2018): 1482.https://doi.org/10.3390/molecules23061482 12. 赵彩秀,王楠,黄鑫,越皓,郭云龙,刘淑莹.枯草芽孢杆菌JLGA-SD-28转化人参皂苷Rb1的特性及其全基因组测序分析[J].中成药,2021,43(02):518-523. 11. 陈佳欣,闫岩,张学武,张洪江.人参皂苷Compound K通过调控AKT/mTOR通路诱导人肝癌细胞自噬作用的研究[J].时珍国医国药,2020,31(06):1347-1350. 10. 陈佳欣,闫岩,苏杰琳,赵嘉琪,张学武.人参皂苷Compound K通过Bcl-2相关转录因子1诱导人肝癌细胞SMMC-7721自噬的作用[J].延边大学医学学报,2020,43(03):157-161. 9. 夏晚霞, 张尚微, 葛亚中,等. 乳酸菌发酵转化人参皂苷[J]. 现代食品科技, 2018, 34(09):136-142. 8. 李雪晴, 李丽, 刘秀峰,等. 三七皂苷的人肠道菌群体外代谢研究[J]. 药物生物技术, 2017(03):34-39. 7. 韩铭鑫, 李方彤, 张琰,等. 稀有原人参二醇型皂苷的人肠道菌群生物转化[J]. 高等学校化学学报, 2019, 40(7). 6. 钟雅婷 茅仁刚 宋纯清 等. RP-HPLC同时测定西洋参总皂苷转化产物中人参皂苷Rg1 Rh1 Rd Rg3和C-K的含量[J]. 江西中医药 2012 43(8):61-64. 5. 方磊,陈红,余晓斌.高转化人参皂苷菌株筛选鉴定及发酵培养基优化[J].食品与发酵工业,2017,43(04):147-151. 4. 杨伟 滕林 丁家望 等. 人参皂苷compound K对小鼠心肌梗死后心室重构的保护及免疫机制研究[J]. 心肺血管病杂志 2016 35(006):478-481. 3. 魏群 张璇 张学武.人参皂苷CK诱导人肝癌SMMC-7721细胞凋亡的内质网应激作用机制[J].时珍国医国药 2018 29(12):2896-2899. 2. 孟雪 邱智东 王蕾 等. 人参皂苷CK抑制人结肠癌SW480细胞增殖的机制研究[J]. 中草药 2020(6). 1. 陈佳欣 闫岩 张学武 等. 人参皂苷CK抑制STAT3诱导人肝癌细胞凋亡的内质网应激作用机制的研究[J]. 时珍国医国药 2020年31卷4期 796-799页 PKU CSCD CA 2020.