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氨甲蝶呤

    
分析标准品,HPLC≥98%

MTX

源叶
B25455 一键复制产品信息
59-05-2
C20H22N8O5
454.44
MFCD00064370
甲氨蝶呤;甲氨基叶酸;氨甲叶酸;对-[(2,4-二氨基喋啶-6)-N-甲基甲氨基]苯甲酰谷氨酸;二水合氨甲嘌呤;(+)氨甲蝶呤;N-[4-[[(2,4-二氨基-6-蝶啶)甲基]甲氨基]苯甲酰]-L-谷氨酸
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
B25455-50mg促销
分析标准品,HPLC≥98%

¥200.00 ¥140.00

>10 3 2 - -
产品介绍 参考文献(59篇) 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

 Methotrexate (Amethopterin) 是一种抗代谢 (antimetabolite) 和抗叶酸剂 (antifolate),可抑制二氢叶酸还原酶,从而防止叶酸转化为四氢叶酸并抑制 DNA 合成。Methotrexate也是一种免疫抑制剂和抗肿瘤剂,用于类风湿关节炎和研究多种癌症 (如急性淋巴细胞白血病)。

SMILES: O=C(O)[C@@H](NC(C1=CC=C(N(CC2=NC3=C(N)N=C(N)N=C3N=C2)C)C=C1)=O)CCC(O)=O
熔点: 195°C
比旋光度: 21 ° (C=0·1, 1N NaOH)
外观: 黄色结晶性粉末
溶解性: DMSO  :  ≥  50  mg/mL  (110.03  mM)
敏感性: 对光和湿度敏感
储存条件: -20℃
密度: 1.536
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献(59篇)

54. [IF=6.5] Xuechun Cheng, et al. "Unraveling the pyroptosis pathway: Key insights into methotrexate-induced liver injury"BIOCHEMICAL PHARMACOLOGY, 2026 May;:118065 53. [IF=11.3] Xu Gao, et al. "Targeting 5-methylcytosine RNA methylation–mediated CX26/IκBα/NF-κB signaling by salvianolic acid B attenuates rheumatoid arthritis progression"PHYTOMEDICINE, 2026 May;:158300 52. [IF=8.3] Ya Li et al."Novel mechanism by which geniposide alleviates rheumatoid arthritis: Targeted inhibition of SphK1 negatively regulates S1P signaling, promotes HIF-1α acetylation-mediated degradation and blocks the VEGF-induced synovial angiogenesis."PHYTOMED￿웿 51. [IF=8.3] Meng-yuan Zhou et al."Salvianolic acid B alleviates rheumatoid arthritis by inhibiting oxidative stress and pyroptosis through the Keap1-Nrf2/ROS/NLRP3 axis."PHYTOMEDICINE.2025 Dec;:157736 50. [IF=5.4] Li Yang et al."Dendropanax proteus root and its major bio-phytochemicals alleviate rheumatoid arthritis by inhibiting TLR4/CLEC1B/PI3K/Akt/NF-κB pathways: proteomics, metabolomics, collagen-induced arthritis rats, MH7A cells, molecular docking, and molecu 49. [IF=5.4] Siyu Zhao et al."Extracts and pimaradienoic acid from Eleutherococcus trifoliatus L. S. Y. Hu for the treatment of Rheumatoid Arthritis by modulating NF-κB signaling pathway."JOURNAL OF ETHNOPHARMACOLOGY.2026 Jan;354:120507 48. [IF=13.2] Jian Chen et al."Liensinine diperchlorate-loaded microneedle patch attenuates rheumatoid arthritis progression by targeting glycolysis-mediated KIF20A/PTEN/AKT positive feedback loop."CHEMICAL ENGINEERING JOURNAL.2025 Aug;:167374 47. [IF=13.2] Jian Chen et al."Liensinine diperchlorate-loaded microneedle patch attenuates rheumatoid arthritis progression by targeting glycolysis-mediated KIF20A/PTEN/AKT positive feedback loop."CHEMICAL ENGINEERING JOURNAL.2025 Aug;:167374 46. [IF=6.3] Xu Gao et al."Oxyimperatorin Suppresses the Pathologies of Rheumatoid Arthritis and the Growth of Synovial Organoids Through Targeting the PI3K/AKT Pathway."PHYTOTHERAPY RESEARCH.2025 Jul;: 45. [IF=2.2] Xiaoqian Wu et al."Mechanistic insights into the anti-rheumatoid arthritis effects of ursolic acid from Periploca forrestii Schltr. via network pharmacology, molecular docking, and experimental Validation."BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIO 44. [IF=4.7] Man-yu Zhang et al."Acetazolamide as an aquaporin 1 inhibitor mitigates rheumatoid arthritis by reducing angiogenesis via the modulation of the FAK-PI3K/Akt signaling pathway."INTERNATIONAL IMMUNOPHARMACOLOGY.2025 Jun;158:114845 43. [IF=6.2] Hong-fei Wang et al."STING signaling contributes to methotrexate-induced liver injury by regulating ferroptosis in mice."ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY.2024 Nov;287:117306 42. [IF=3.1] Yueyue Li et al."Application of a dual channel MPTS-modified two-dimensional cell membrane chromatography system for rapid screening of effective ingredients in Saposhnikovia divaricata targeting inflammatory macrophages and fibroblast synovial cells in t 41. [IF=5.1] Yang Yang et al."Protective effect of multiple strains of Lactobacillus acidophilus combined on collagen-induced arthritis."Food & Function.2024 Dec;: 40. [IF=4.8] Zhang Man-yu et al."Silencing aquaporin 1 inhibits autophagy to exert anti-rheumatoid arthritis effects in TNF-α-induced fibroblast-like synoviocytes and adjuvant-induced arthritis rats."INFLAMMATION RESEARCH.2025 Dec;74(1):1-19 39. [IF=2] Pengqiang ZHANG et al."Protective effect of lappaconitine on Freund's complete adjuvant-induced arthritis exerted through P2X7 receptor-mediated regulation of M1/M2 balance in rats."Journal of Traditional Chinese Medicine.2025 Jan;45(1):39 38. [IF=5.7] Yang Yang et al."Bifidobacterium animalis BD400 protects from collagen-induced arthritis through histidine metabolism."Frontiers in Immunology.2025 Jan;16: 37. [IF=14.3] Guanghe Xue et al."Dual Targeting Biomimetic Carrier-Free Nanosystems for Photo-Chemotherapy of Rheumatoid Arthritis via Macrophage Apoptosis and Re-Polarization."Advanced Science.2025 Jan;:2406877 36. [IF=4.8] Sheng-long Gu et al."Eupalinolide B alleviates rheumatoid arthritis through the promotion of apoptosis and autophagy via regulating the AMPK/mTOR/ULK-1 signaling axis."INTERNATIONAL IMMUNOPHARMACOLOGY.2025 Feb;148:114179 35. [IF=6.1] Cao Bochun et al."Innovative biomarkers TCN2 and LY6E can significantly inhibit respiratory syncytial virus infection."Journal of Translational Medicine.2024 Dec;22(1):1-18 34. [IF=5.6] Juan He et al."Novel artesunate and isatin hybrid CT3-1 suppresses collagen-induced arthritis through abrogating dendritic cell chemotaxis-induced by CCR5."INTERNATIONAL IMMUNOPHARMACOLOGY".2024 Jul;136:112264 33. [IF=5.4] Weiliang Fu et al."Network pharmacology combined with affinity ultrafiltration to elucidate the potential compounds of Shaoyao Gancao Fuzi Decoction for the treatment of rheumatoid arthritis."JOURNAL OF ETHNOPHARMACOLOGY".2024 Aug;330:118268 32. [IF=8.2] Zhenqi Sang et al."A green, efficient and stable platform based on hyperbranched quaternized hydrothermal magnetic chitosan nanospheres integrated cytomembranes for screening drug candidates from natural products."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROM 31. [IF=7.9] Xian Lin et al."Sesamol serves as a p53 stabilizer to relieve rheumatoid arthritis progression and inhibits the growth of synovial organoids."PHYTOMEDICINE.10.1016/j.phymed.2023.155109 30. [IF=2.9] Jiao Wang et al."A Q-marker screening strategy based on ADME studies and systems biology for Chinese herbal medicine, taking Qianghuo Shengshi decoction in treating rheumatoid arthritis as an example."Molecular Omics.2023 Jul;: 29. [IF=8] Kaixuan Zhao et al."Gentiopicroside-Loaded Chitosan Nanoparticles Inhibit TNF-α-Induced Proliferation and Inflammatory Response in HaCaT Keratinocytes and Ameliorate Imiquimod-Induced Dermatitis Lesions in Mice."International Journal of Nanomedicine. 28. [IF=6.656] Fang-yuan Liu et al."Therapeutic effects of shikonin on adjuvant-induced arthritis in rats and cellular inflammation, migration and invasion of rheumatoid fibroblast-like synoviocytes via blocking the activation of Wnt/β-catenin pathway."PHYTOMEDICINE.202 27. [IF=0] Xian Lin et al."Osthole regulates N6-methyladenosine-modified TGM2 to inhibit the progression of rheumatoid arthritis and associated interstitial lung disease."MedComm.2023 Feb;4(2):e219 26. [IF=6.986] Gan Peirong et al."A novel mechanism for inhibiting proliferation of rheumatoid arthritis fibroblast-like synoviocytes: geniposide suppresses HIF-1α accumulation in the hypoxic microenvironment of synovium."INFLAMMATION RESEARCH.2022 Sep;:1-14 25. [IF=5.307] Jian Chen et al."Novel isatin-based hybrids as potential anti-rheumatoid arthritis drug candidates: Synthesis and biological evaluation."BIOORGANIC CHEMISTRY.2022 Nov;128:106063 24. [IF=3.846] Shichao Wu et al."Methotrexate and 10-hydroxycamptothecine loaded pullulan nanoparticles with the targeting property for efficient cancer therapy."MATERIALS TECHNOLOGY 23. [IF=4.932] Bo Meng et al."AMSP-30 m as a novel HIF-1α inhibitor attenuates the development and severity of adjuvant-induced arthritis in rats: Impacts on synovial apoptosis, synovial angiogenesis and sonic hedgehog signaling pathway."Int Immunopharmacol. 2022 Feb;10 22. [IF=2.589] Shenghui Zhong et al."Hyaluronic Acid-Coated MTX-PEI Nanoparticles for Targeted Rheumatoid Arthritis Therapy."Crystals. 2021 Apr;11(4):321 21. [IF=3.361] Xiangyu Li et al."Folate receptor-targeting mesoporous silica-coated gold nanorod nanoparticles for the synergistic photothermal therapy and chemotherapy of rheumatoid arthritis."Rsc Adv. 2021 Jan;11(6):3567-3574 20. [IF=3.943] Yu-rong Mu et al."Acetazolamide ameliorates the severity of collagen-induced arthritis in rats: Involvement of inducing synovial apoptosis and inhibiting Wnt/β-catenin pathway."Int Immunopharmacol. 2021 Jan;90:107214 19. [IF=5.34] Li Cai et al."7-Hydroxycoumarin mitigates the severity of collagen-induced arthritis in rats by inhibiting proliferation and inducing apoptosis of fibroblast-like synoviocytes via suppression of Wnt/β-catenin signaling pathway."Phytomedicine. 2022 Jan;94: 18. [IF=5.455] He Lianhua et al."Shikonin attenuates rheumatoid arthritis by targeting SOCS1/JAK/STAT signaling pathway of fibroblast like synoviocytes."Chin Med-Uk. 2021 Dec;16(1):1-15 17. [IF=7.727] Lina Guo et al."Rational design of metal-organic frameworks to deliver methotrexate for targeted rheumatoid arthritis therapy."J Control Release. 2021 Feb;330:119 16. [IF=2.496] Jiang Wei et al."Synthesis and characterization of magnetic mesoporous core–shell nanocomposites for targeted drug delivery applications."J Porous Mat. 2017 Feb;24(1):257-265 15. [IF=2.69] Juan Wu et al."Facile synthesis of magnetic-/pH-responsive hydrogel beads based on Fe3O4 nanoparticles and chitosan hydrogel as MTX carriers for controlled drug release."J Biomat Sci-Polym E. 2016;27(15):1553-1568 14. [IF=3.329] Chengcheng Zou et al."Functional analysis of miR-181a and Fas involved in hepatitis B virus-related hepatocellular carcinoma pathogenesis."Exp Cell Res. 2015 Feb;331:352 13. [IF=4.101] Kejia Wang et al."Flap endonuclease 1 is a promising candidate biomarker in gastric cancer and is involved in cell proliferation and apoptosis."Int J Mol Med. 2014 May;33(5):1268-1274 12. [IF=4.421] Fei Hao et al."Targeted Co-Delivery of siRNA and Methotrexate for Tumor Therapy via Mixed Micelles."Pharmaceutics. 2019 Feb;11(2):92 11. [IF=4.471] Jinlong Zhao et al."Multifunctional folate receptor-targeting and pH-responsive nanocarriers loaded with methotrexate for treatment of rheumatoid arthritis."Int J Nanomed. 2017; 12: 6735–6746 10. Li, Xiangyu, et al. "Folate receptor-targeting mesoporous silica-coated gold nanorod nanoparticles for the synergistic photothermal therapy and chemotherapy of rheumatoid arthritis." RSC Advances 11.6 (2021): 3567-3574.https://doi.org/10.1039/D0RA08689D 9. Mu, Y. R. , et al. "Acetazolamide ameliorates the severity of collagen-induced arthritis in rats: Involvement of inducing synovial apoptosis and inhibiting Wnt/β-catenin pathway." International Immunopharmacology 90(2021):107214. 8. Wang, Kejia, Chunhong Xie, and Daorong Chen. "Flap endonuclease 1 is a promising candidate biomarker in gastric cancer and is involved in cell proliferation and apoptosis." International journal of molecular medicine 33.5 (2014): 1268-1274. https://doi.org 7. 李炳彤. 艾拉莫德对类风湿关节炎患者外周血白细胞瓜氨酸化的影响及机制研究[D].吉林大学,2020. 6. 任泽宇,姜宏,许燕,石永芳.甲氨蝶呤PLGA微球制备工艺及体外释药性能考察[J].石河子大学学报(自然科学版),2020,38(06):767-772. 5. 段紫钰,李建国,陈静,刘鸿伟,李丽娜,周武,张守民.凉血消银颗粒剂对银屑病转基因小鼠模型miR-155/SOCS1轴的影响[J].天津医药,2020,48(11):1045-1049. 4. 刘春芳, 何莲花, 王靖霞,等. 风湿祛痛胶囊对类风湿关节炎滑膜Akt和MAPK信号通路的影响[J]. 中国实验方剂学杂志, 2019, 25(13):43-48. 3. 王靖霞, 刘春芳, 何莲花, et al. 风湿祛痛胶囊对大鼠胶原诱导性关节炎的影响[J]. 中国实验方剂学杂志, 2019, 25(02):89-95. 2. 刘春芳, 王靖霞, 何莲花,等. 风湿祛痛胶囊对Ⅱ型胶原诱导性关节炎大鼠滑膜血管新生的影响[J]. 中国中药杂志, 2019, 044(007):1457-1463. 1. 王靖霞, 刘春芳, 李逸群,等. 雷公藤多苷片抑制实验性类风湿关节炎血管新生的作用研究. 中国中药杂志.

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