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替加环素

    
分析标准品,HPLC≥98%

Tigecycline

源叶
B25905 一键复制产品信息
220620-09-7
C29H39N5O8
585.65
MFCD00935753
(4S,4aS,5aR,12aS)-4,7-双(二甲氨基)-9-[(叔丁基氨基)乙酰胺基]-3,10,12,12a-四羟基-1,11-二氧代-1,4,4a,5,5a,6,11,12a-八氢并四苯-2-甲酰胺
货号 规格 价格 上海 北京 珠海 重庆 武汉 购买数量
B25905-20mg促销
分析标准品,HPLC≥98%

¥360.00 ¥300.00

>10 4 4 - 1
产品介绍 参考文献(20篇) 质检证书(COA) 摩尔浓度计算器 相关产品

产品介绍

 Tigecycline (GAR-936) 是一种广谱的甘氨酰环素抗生素。Tigecycline 对 E. coli (MG1655 菌株) 的平均抑制浓度 (MIC) 约为 125 ng/ mL。对 Acinetobacter baumannii (A. baumannii) 的 MIC50 和 MIC90 分别为 1 和 2 mg/L。

SMILES: O=C(C(C1=O)=C(O)[C@@H](N(C)C)[C@]2([H])C[C@]3([H])CC4=C(C(C3=C(O)[C@@]21O)=O)C(O)=C(NC(CNC(C)(C)C)=O)C=C4N(C)C)N
熔点: 164-166°C
沸点: 890.922°C at 760 mmHg
外观: Orange powder
溶解性: DMSO  :  150  mg/mL  (256.13  mM;  Need  ultrasonic)

H2O  :  8.33  mg/mL  (14.22  mM;  ultrasonic  and  warming  and  heat  to  60°C)
储存条件: 2-8℃
密度: 1.455
注意: 部分产品我司仅能提供部分信息,我司不保证所提供信息的权威性,仅供客户参考交流研究之用。

参考文献(20篇)

15. [IF=4.5] Yongtian Yuan et al."Antibacterial activity and mechanism of naphthoquine phosphate against ceftazidime-resistant Acinetobacter baumannii via cell membrane disruption and ROS induction."Frontiers in Microbiology.2025 Aug;16: 14. [IF=4.8] Jie Wu et al."Screening and comparison of in vitro-induced resistant and clinically resistant Stenotrophomonas maltophilia strains for eravacycline resistance-related genes."Frontiers in Cellular and Infection Microbiology.2025 Aug;15: 13. [IF=4.5] Yongtian Yuan et al."Antibacterial activity and mechanism of naphthoquine phosphate against ceftazidime-resistant Acinetobacter baumannii via cell membrane disruption and ROS induction."Frontiers in Microbiology.2025 Aug;16: 12. [IF=4.8] Jie Wu et al."Screening and comparison of in vitro-induced resistant and clinically resistant Stenotrophomonas maltophilia strains for eravacycline resistance-related genes."Frontiers in Cellular and Infection Microbiology.2025 Aug;15: 11. [IF=4.2] Chong Chen et al."Genomic Diversity of the tet(X)-Positive Myroides Species."Microorganisms.2025 Jun;13(6):1180 10. [IF=6.7] Mengxiang Zheng et al."Curcumin reverses high-level tigecycline resistance mediated by different mechanisms in Gram-negative bacteria."PHYTOMEDICINE.2024 Dec;:156319 9. [IF=3.8] Juan Wang et al."Research note: Prevalence and genetic characteristics of pathogenic E. coli isolates from domestic pigeons in central China."POULTRY SCIENCE.2025 Feb;104:104705 8. [IF=5] Fulei Li et al."Inosine reverses multidrug resistance in Gram-negative bacteria carrying mobilized RND-type efflux pump gene cluster tmexCD-toprJ."mSystems. 7. [IF=6.4] Yang# Jindian et al."Repurposing harmaline as a novel approach to reverse tmexCD1-toprJ1-mediated tigecycline resistance against klebsiella pneumoniae infections."Microbial Cell Factories".2024 Dec;23(1):1-17 6. [IF=7.9] Xia Xiao et al."Gramine sensitizes Klebsiella pneumoniae to tigecycline killing."PHYTOMEDICINE".2024 Feb;:155421 5. [IF=3.9] Jie Wu et al."In vitro Antimicrobial Activity and Dose Optimization of Eravacycline and Other Tetracycline Derivatives Against Levofloxacin-Non-Susceptible and/or Trimethoprim-Sulfamethoxazole-Resistant Stenotrophomonas maltophilia."Infection and Drug Resi 4. [IF=5.988] Wei Lu et al."An LC-MS/MS method for the simultaneous determination of 18 antibacterial drugs in human plasma and its application in therapeutic drug monitoring."Frontiers in Pharmacology.2022 Nov 8;13:1044234 3. [IF=5.882] Zi-Jian Zheng et al."MALDI-TOF MS for rapid detection and differentiation between Tet(X)-producers and non-Tet(X)-producing tetracycline-resistant Gram-negative bacteria."Virulence. 2022;13(1):77-88 2. [IF=4.003] Hui Zhang et al.In vitro and in vivo Activity of Combinations of Polymyxin B with Other Antimicrobials Against Carbapenem-Resistant Acinetobacter baumannii.Infect Drug Resist. 2021 Nov;14:4657-4666 1. 马霖 孙加琳 李恩泽 等. LC-MS/MS法同时测定人血浆中伏立康唑和替加环素的浓度[J]. 中国临床药理学杂志 2019 035(024):3237-3240.

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