| 货号 | 规格 | 价格 | 上海 | 北京 | 武汉 | 南京 | 购买数量 |
|---|---|---|---|---|---|---|---|
S80212-2mg |
99.1% | ￥140.00 | 5 | - | - | - |
|
S80212-5mg |
99.1% | ￥290.00 | 6 | - | - | - |
|
S80212-10mg |
99.1% | ￥470.00 | 6 | - | - | - |
|
S80212-25mg |
99.1% | ￥800.00 | 6 | - | - | - |
|
S80212-50mg |
99.1% | ￥1400.00 | 5 | - | - | - |
|
S80212-100mg |
≥96% | ￥2350.00 | 货期：2-3天 | - | - | - |
|
Pimasertib (AS703026) is a highly selective, ATP non-competitive allosteric orally available MEK1/2 inhibitor
| 产品描述： | Pimasertib (AS703026) is a highly selective, ATP non-competitive allosteric orally available MEK1/2 inhibitor | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点： | MEK1;MEK2;MEK | ||||||||||||||||||||
| 体内研究： | Pimasertib (15, 30 mg/kg) significantly inhibits the growth of tumor in the human H929 MM xenograft model in CB17 SCID mice. Pimasertib (10 mg/kg, p.o.) inhibits tumor growth of cetuximab-resistant tumor attributed by K-ras mutation | ||||||||||||||||||||
| 参考文献： | 1. Kim K, et al. Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo. Br J Haematol, 2010, 149(4), 537-549. 2. Park SJ, et al. The MEK1/2 inhibitor AS703026 circumvents resistance to the BRAF inhibitor PLX4032 in human malignant melanoma cells. Am J Med Sci. 2013 Dec;346(6):494-8. 3. Yoon J, et al. MEK1/2 inhibitors AS703026 and AZD6244 may be potential therapies for KRAS mutated colorectal cancer that is resistant to EGFR monoclonal antibody therapy. Cancer Res, 2011, 71(2), 445-453. | ||||||||||||||||||||
| 溶解性： | DMSO : ≥ 100 mg/mL (231.91 mM) | ||||||||||||||||||||
| 保存条件： | -20℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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