| 货号 | 规格 | 价格 | 上海 | 北京 | 珠海 | 重庆 | 武汉 | 购买数量 |
|---|---|---|---|---|---|---|---|---|
S80605-5mg买3赠1 |
99.44% | ￥240.00 |
>10 | 2 | 2 | - | - |
|
S80605-10mg买3赠1 |
99.44% | ￥400.00 |
>10 | - | - | - | - |
|
S80605-25mg买3赠1 |
99.44% | ￥880.00 |
>10 | 2 | 2 | - | - |
|
S80605-50mg买3赠1 |
≥99% | ￥1600.00 |
>10 | - | - | - | - |
|
| 产品描述： | CH-223191 is a potent and specific antagonist of aryl hydrocarbon receptor (AhR). CH-223191 inhibits TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibits TCDD-induced luciferase activity with an IC50 of 0.03 μM | ||||||||||||||||||||
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| 靶点： | Aryl Hydrocarbon Receptor;AhR;ArylHydrocarbonReceptor | ||||||||||||||||||||
| 体内研究： | CH-223191 (10 mg/kg; once a day; 25 days) suppresses cytochrome P450 1A1 expression and the intrahepatocyte fat content in liver, reduces activity of AST and ALT in TCDD-treated mice | ||||||||||||||||||||
| 参考文献： | 1. Kim SH, et al. Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor. Mol Pharmacol. 2006 Jun;69(6):1871-8. Epub 2006 Mar | ||||||||||||||||||||
| 溶解性： | DMSO : 62.5 mg/mL (187.47 mM; ultrasonic and warming and heat to 60°C) | ||||||||||||||||||||
| 保存条件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液浓度参考： |
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| 注意： | 部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
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