| 产品描述： | Optovin is a reversible photoactivated TRPA1 ligand that enables light-mediated neuronal excitation. Optovin activates TRPA1 via structure-dependent photochemical reactions with redox-sensitive cysteine residues |
| 靶点： |
TRP Channel;TRP/TRPVChannel |
| 体外研究： |
Optovin (1-10 μM) increases Zebrafish embryos motor activity greater than 40 standard deviations above the control mean at the photic stimuli, with an EC50 of 2 μM. Optovin (100 μM; 120 s) strongly activates 33% (35/105) of dorsal root ganglia (DRG) neurons. Optovin (10 μM; 1 min) activates HEK293T cells transfected with hTrpA1 |
| 体内研究： |
Optovin (1-10 μM) causes light-dependent motor excitation in vivo. Optovin (15 mM (20 μL); on the ear) elicits nociceptive behaviors in adult mice. Optovin (10 μM; 96 h) do not affect the appearance, touch response, heart rate, fin movements, morphology or percentage survival of larvae and adult zebrafish |
| 参考文献： |
1. Kokel D, et al. Photochemical activation of TRPA1 channels in neurons and animals. Nat Chem Biol. 2013 Apr;9(4):257-63. |
| 溶解性： |
soluble in DMSO |
| 保存条件： |
-20℃ |
| 配置溶液浓度参考： |
|
1mg |
5mg |
10mg |
| 1 mM |
3.17 ml |
15.852 ml |
31.704 ml |
| 5 mM |
0.634 ml |
3.17 ml |
6.341 ml |
| 10 mM |
0.317 ml |
1.585 ml |
3.17 ml |
| 50 mM |
0.063 ml |
0.317 ml |
0.634 ml |
|
| 注意： |
部分产品我司仅能提供部分信息，我司不保证所提供信息的权威性，仅供客户参考交流研究之用。 |
上海工商
危险品化学品经营许可证（不带存储）
营业执照(三证合一)
北京